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Gadodiamide Side Effects

The most commonly reported side effects of gadodiamide include nephrogenic systemic fibrosis, nephrogenic systemic fibrosis, and pain, based on 3,348 FDA adverse event reports from 2004 to 2025.

Gadodiamide side effects

Percentages show how often each reaction appears relative to total reports for gadodiamide.

1
Nephrogenic Systemic Fibrosis40.4%1,351
2
Nephrogenic Systemic Fibrosis26.3%879
3
Pain15.1%506
4
Anxiety8.9%299
5
Emotional Distress8.1%272
6
Mobility Decreased7.7%259
7
General Physical Health Deterioration7.6%255
8
Fibrosis7.6%254
9
Pain7.6%254
10
Skin Induration6.8%229
11
Oedema Peripheral6.8%228
12
Skin Hypertrophy6.7%224
13
Arthralgia6.4%215
14
Injury6.3%211
15
Scar6.3%210

These are voluntary reports and do not establish that gadodiamide caused these reactions.

Report severity

92.6%Serious3,101 reports
9.3%Hospitalizations311 reports
11.2%Fatal375 reports

Seriousness is determined by the reporter, not by OpenClaim.

Gadodiamide drug interactions

Other drugs that appear in adverse event reports alongside gadodiamide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Gadopentetate-dimeglumine35.1%1,175
2
Gadoversetamide24.7%826
3
Gadobenate-dimeglumine22.6%757
4
Gadoteridol17.1%574
5
Gadoxetate-disodium4.5%152
6
Gadoterate-meglumine1.4%47
7
Tirofiban-hydrochloride1.1%37
8
Gadobutrol1.0%34
9
Meglumine0.5%18
10
Iohexol0.5%16
11
Iodixanol0.4%13
12
Iopamidol0.2%8
13
Metoprolol0.1%4
14
Lidocaine0.1%4
15
Mannitol0.1%4

Taken alongside

1
Estropipate11.7%392
2
Sevelamer9.1%304
3
Warfarin8.5%283
4
Prednisone8.5%283
5
Metoprolol8.2%276
6
Furosemide6.8%226
7
Amlodipine6.5%219
8
Aspirin6.5%216
9
Calcium-acetate6.0%200
10
Acetaminophen5.3%177
11
Gabapentin5.0%168
12
Mycophenolate4.3%143
13
Insulin4.2%140
14
Lisinopril4.0%134
15
Levothyroxine-sodium3.8%127

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports gadodiamide side effects

43.0% of gadodiamide adverse event reports involve female patients and 43.2% involve male patients. The largest age group is adult at 77%. These figures reflect who reports side effects, not underlying risk.

Sex

Female43.0%
Male43.2%
Unknown13.8%

Age group

< 20.3%
2–110.8%
12–171.6%
18–6477.4%
65+19.9%

What is gadodiamide used for

Conditions and purposes for which patients were taking gadodiamide when the adverse event was reported.

AbasiaAbdomen ScanAbdominal AbscessAbdominal MassAbdominal PainAbdominal Pain LowerAbdominal Pain UpperAbnormal BehaviourAbnormal Loss Of WeightAbscessAbscess DrainageAbscess FungalAcoustic NeuritisAcoustic NeuromaAcute Abdomen

Showing 15 of 665 indications

Gadodiamide brand names and reporting trend

Gadodiamide is sold under the brand name Omniscan.

Brand names

Omniscan58

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking gadodiamide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.