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Gadobenate Side Effects

The most commonly reported side effects of gadobenate include nephrogenic systemic fibrosis, pain, and nausea, based on 4,338 FDA adverse event reports from 2005 to 2025.

Gadobenate side effects

Percentages show how often each reaction appears relative to total reports for gadobenate.

1
Nephrogenic Systemic Fibrosis10.5%454
2
Pain8.5%367
3
Nausea7.7%335
4
Vomiting6.9%298
5
Hypersensitivity6.3%272
6
Nausea6.2%270
7
Pain5.9%257
8
Urticaria5.5%239
9
Anxiety5.5%238
10
Arthralgia5.3%231
11
Burning Sensation5.3%229
12
Gadolinium Deposition Disease5.3%228
13
Vomiting5.1%223
14
Dyspnoea5.1%222
15
Paraesthesia5.0%219

These are voluntary reports and do not establish that gadobenate caused these reactions.

Report severity

60.9%Serious2,644 reports
17.2%Hospitalizations745 reports
4.7%Fatal205 reports

Seriousness is determined by the reporter, not by OpenClaim.

Gadobenate drug interactions

Other drugs that appear in adverse event reports alongside gadobenate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Gadodiamide17.8%774
2
Gadopentetate-dimeglumine17.1%742
3
Gadoversetamide15.1%657
4
Gadoteridol11.8%512
5
Gadoxetate-disodium3.6%154
6
Gadoterate-meglumine1.1%46
7
Gadobutrol0.9%39
8
Aspirin0.4%19
9
Clopidogrel-bisulfate0.4%18
10
Cyclophosphamide0.1%6
11
Tocilizumab0.1%5
12
Fludarabine-phosphate0.1%5
13
Fingolimod<0.1%4
14
Apremilast<0.1%4
15
Diphenhydramine<0.1%4

Taken alongside

1
Acetaminophen4.3%185
2
Metoprolol4.1%177
3
Estropipate3.7%159
4
Sevelamer3.6%157
5
Aspirin3.5%151
6
Amlodipine3.4%149
7
Prednisone3.4%147
8
Levothyroxine-sodium3.3%141
9
Gabapentin3.2%140
10
Warfarin3.1%136
11
Furosemide3.1%135
12
Atorvastatin-calcium2.7%115
13
Lisinopril2.6%114
14
Insulin2.5%108
15
Hydrocodone2.4%102

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports gadobenate side effects

54.8% of gadobenate adverse event reports involve female patients and 36.2% involve male patients. The largest age group is adult at 73%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.8%
Male36.2%
Unknown9.0%

Age group

< 20.1%
2–111.1%
12–172.3%
18–6472.5%
65+24.0%

What is gadobenate used for

Conditions and purposes for which patients were taking gadobenate when the adverse event was reported.

Abdominal DistensionAbdominal MassAbdominal PainAbscessAcoustic NeuromaAcute Coronary SyndromeAdnexa Uteri MassAdrenal CystAgeusiaAlcoholic PancreatitisAmblyopiaAmnesiaAneurysmAngiocardiogramAngiogram

Showing 15 of 444 indications

Gadobenate brand names and reporting trend

Gadobenate is sold under the brand name Multihance Multipack.

Brand names

Multihance Multipack234

Quarterly reports (20052025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking gadobenate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.