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Futibatinib Side Effects

The most commonly reported side effects of futibatinib include diarrhoea, death, and disease progression, based on 183 FDA adverse event reports from 2021 to 2025.

Futibatinib side effects

Percentages show how often each reaction appears relative to total reports for futibatinib.

1
Diarrhoea17.5%32
2
Death16.9%31
3
Disease Progression16.4%30
4
Hyperphosphataemia13.7%25
5
Fatigue13.1%24
6
Nausea12.6%23
7
Dry Mouth11.5%21
8
Off Label Use10.4%19
9
Vomiting8.7%16
10
Dry Eye8.7%16
11
Neuropathy Peripheral7.7%14
12
Constipation7.7%14
13
Pain In Extremity7.1%13
14
Asthenia7.1%13
15
Decreased Appetite6.6%12

These are voluntary reports and do not establish that futibatinib caused these reactions.

Report severity

68.3%Serious125 reports
32.8%Hospitalizations60 reports
22.4%Fatal41 reports

Seriousness is determined by the reporter, not by OpenClaim.

Futibatinib drug interactions

Other drugs that appear in adverse event reports alongside futibatinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pembrolizumab7.7%14
2
Cisplatin5.5%10
3
Pemigatinib3.8%7
4
Binimetinib3.3%6
5
Fluorouracil3.3%6
6
Gemcitabine2.7%5
7
Ferric-citrate2.2%4
8
Sevelamer1.6%3
9
Capecitabine1.6%3
10
Erdafitinib1.6%3
11
Acetazolamide1.1%2
12
Calcitonin1.1%2
13
Trastuzumab1.1%2
14
Paclitaxel1.1%2
15
Ramucirumab1.1%2

Taken alongside

1
Ondansetron20.2%37
2
Prochlorperazine16.9%31
3
Pantoprazole-sodium13.1%24
4
Oxycodone12.0%22
5
Acetaminophen11.5%21
6
Gabapentin10.9%20
7
Omeprazole10.4%19
8
Sevelamer8.7%16
9
Polyethylene-glycol-33508.2%15
10
Furosemide8.2%15
11
Metoprolol8.2%15
12
Loperamide-hydrochloride8.2%15
13
Atorvastatin-calcium7.7%14
14
Ergocalciferol7.1%13
15
Famotidine7.1%13

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports futibatinib side effects

51.9% of futibatinib adverse event reports involve female patients and 39.9% involve male patients. The largest age group is adult at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.9%
Male39.9%
Unknown8.2%

Age group

< 20.0%
2–110.6%
12–170.0%
18–6459.9%
65+39.5%

What is futibatinib used for

Conditions and purposes for which patients were taking futibatinib when the adverse event was reported.

Adenocarcinoma GastricAdenoid Cystic CarcinomaAdrenal Gland CancerAnal Squamous Cell CarcinomaBile Duct CancerBladder CancerBrain NeoplasmBrain Neoplasm MalignantBreast Cancer FemaleBreast Cancer MetastaticCholangiocarcinomaChronic Lymphocytic LeukaemiaGallbladder CancerGastric CancerHer2 Positive Gastric Cancer

Showing 15 of 33 indications

Futibatinib brand names and reporting trend

Futibatinib is sold under the brand name Lytgobi.

Brand names

Lytgobi67

Quarterly reports (20212025)

202120242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking futibatinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.