OpenClaim

Frovatriptan Side Effects

The most commonly reported side effects of frovatriptan include headache, off label use, and drug ineffective for unapproved indication, based on 1,598 FDA adverse event reports from 2004 to 2025. 17.1% of reports found the drug to be ineffective.

Frovatriptan side effects

Percentages show how often each reaction appears relative to total reports for frovatriptan.

1
Headache18.7%299
2
Off Label Use17.3%277
3
Drug Ineffective17.1%274
4
Drug Ineffective For Unapproved Indication14.4%230
5
Hypersensitivity12.6%201
6
Drug Intolerance12.5%200
7
Migraine12.0%192
8
Swelling Face11.9%190
9
Swollen Tongue11.9%190
10
Dysphonia11.8%189
11
Angioedema11.7%187
12
Nausea8.4%134
13
Dyspnoea7.4%118
14
Product Use In Unapproved Indication7.2%115
15
Diarrhoea6.1%98

These are voluntary reports and do not establish that frovatriptan caused these reactions.

Report severity

61.3%Serious980 reports
18.6%Hospitalizations298 reports
0.7%Fatal11 reports

Seriousness is determined by the reporter, not by OpenClaim.

Frovatriptan drug interactions

Other drugs that appear in adverse event reports alongside frovatriptan. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Topiramate18.8%300
2
Rizatriptan-benzoate17.9%286
3
Sumatriptan16.8%268
4
Propranolol-hydrochloride16.1%257
5
Venlafaxine15.9%254
6
Eszopiclone15.6%250
7
Metoclopramide-hydrochloride15.5%248
8
Acetaminophen13.0%207
9
Duloxetine-hydrochloride12.4%198
10
Zolmitriptan12.2%195
11
Hydromorphone-hydrochloride12.1%193
12
Lansoprazole12.0%192
13
Prednisone12.0%191
14
Ciprofloxacin11.9%190
15
Indomethacin11.8%189

Taken alongside

1
Acetaminophen27.3%436
2
Fluticasone20.2%323
3
Naproxen18.1%290
4
Albuterol16.5%263
5
Duloxetine-hydrochloride15.9%254
6
Pantoprazole-sodium15.9%254
7
Fluoxetine-hydrochloride15.6%249
8
Amitriptyline-hydrochloride15.0%239
9
Ergocalciferol14.5%231
10
Topiramate13.3%213
11
Cefuroxime12.9%206
12
Morphine-sulfate12.8%205
13
Cephalexin12.8%204
14
Metoclopramide-hydrochloride12.7%203
15
Nitrofurantoin12.0%192

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports frovatriptan side effects

84.5% of frovatriptan adverse event reports involve female patients and 8.3% involve male patients. The largest age group is adult at 89%. These figures reflect who reports side effects, not underlying risk.

Sex

Female84.5%
Male8.3%
Unknown7.3%

Age group

< 21.8%
2–110.6%
12–171.2%
18–6488.9%
65+7.6%

What is frovatriptan used for

Conditions and purposes for which patients were taking frovatriptan when the adverse event was reported.

Accidental Exposure To ProductCluster HeadacheCyclic Vomiting SyndromeDrug Exposure During PregnancyDrug Use For Unknown IndicationDysmenorrhoeaFibromyalgiaFoetal Exposure During PregnancyHeadacheHeadacheHypersensitivityIll-defined DisorderIntentional Drug MisuseIll-defined DisorderMigraine

Showing 15 of 31 indications

Frovatriptan brand names and reporting trend

Frovatriptan is sold under the brand name Frova.

Brand names

Frova365

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking frovatriptan with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.