OpenClaim

Fremanezumab Side Effects

The most commonly reported side effects of fremanezumab include accidental exposure to product, injection site pain, and migraine, based on 11,017 FDA adverse event reports from 2014 to 2025. 8.2% of reports found the drug to be ineffective.

Fremanezumab side effects

Percentages show how often each reaction appears relative to total reports for fremanezumab.

1
Accidental Exposure To Product12.8%1,409
2
Injection Site Pain11.4%1,260
3
Migraine8.7%963
4
Drug Ineffective8.2%907
5
Headache6.5%719
6
Injection Site Erythema5.7%626
7
Device Leakage5.0%555
8
Fatigue4.4%489
9
Nausea4.4%482
10
Injection Site Pruritus4.3%479
11
Device Malfunction4.1%457
12
Injection Site Swelling3.9%425
13
Drug Dose Omission By Device3.6%398
14
Incorrect Dose Administered By Device3.4%380
15
Dizziness3.4%370

These are voluntary reports and do not establish that fremanezumab caused these reactions.

Report severity

33.1%Serious3,651 reports
7.4%Hospitalizations812 reports
0.9%Fatal100 reports

Seriousness is determined by the reporter, not by OpenClaim.

Fremanezumab drug interactions

Other drugs that appear in adverse event reports alongside fremanezumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Erenumab-aooe2.4%268
2
Galcanezumab-gnlm1.3%148
3
Rimegepant1.2%135
4
Sodium-oxybate1.0%115
5
Onabotulinumtoxina1.0%108
6
Dupilumab0.9%100
7
Eptinezumab-jjmr0.9%94
8
Topiramate0.8%87
9
Sumatriptan0.6%68
10
Ubrogepant0.5%52
11
Calcium-oxybate0.5%52
12
Magnesium-oxybate0.5%52
13
Potassium-oxybate0.5%52
14
Venlafaxine0.4%47
15
Amitriptyline-hydrochloride0.4%45

Taken alongside

1
Topiramate4.1%447
2
Ergocalciferol3.9%430
3
Acetaminophen3.9%426
4
Sumatriptan3.4%377
5
Gabapentin3.2%351
6
Levothyroxine-sodium3.0%327
7
Ondansetron2.7%300
8
Albuterol2.5%270
9
Rizatriptan-benzoate2.5%270
10
Onabotulinumtoxina2.4%262
11
Omeprazole2.3%251
12
Fluticasone2.2%237
13
Duloxetine-hydrochloride2.1%232
14
Ibuprofen2.1%227
15
Amitriptyline-hydrochloride2.1%226

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports fremanezumab side effects

79.0% of fremanezumab adverse event reports involve female patients and 10.0% involve male patients. The largest age group is adult at 83%. These figures reflect who reports side effects, not underlying risk.

Sex

Female79.0%
Male10.0%
Unknown11.1%

Age group

< 20.2%
2–11<0.1%
12–170.8%
18–6482.7%
65+16.2%

What is fremanezumab used for

Conditions and purposes for which patients were taking fremanezumab when the adverse event was reported.

Abdominal MigraineAbdominal MigraineAdverse Drug ReactionAdverse EventAlopeciaAnkylosing SpondylitisBlepharospasmBalance DisorderBrain InjuryCervicogenic HeadacheCluster HeadacheColitis UlcerativeComplex Regional Pain SyndromeCentral Nervous System LesionCerebrovascular Accident

Showing 15 of 83 indications

Fremanezumab brand names and reporting trend

Fremanezumab is sold under the brand name Ajovy.

Brand names

Ajovy428

Quarterly reports (20142025)

2014202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking fremanezumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.