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Fostamatinib Side Effects

The most commonly reported side effects of fostamatinib include diarrhoea, platelet count decreased, and product dose omission issue, based on 6,664 FDA adverse event reports from 2006 to 2025. 5.5% of reports found the drug to be ineffective.

Fostamatinib side effects

Percentages show how often each reaction appears relative to total reports for fostamatinib.

1
Diarrhoea13.9%928
2
Platelet Count Decreased12.6%841
3
Product Dose Omission Issue10.8%717
4
Off Label Use10.5%703
5
Hospitalisation6.3%423
6
Platelet Count5.7%378
7
Drug Ineffective5.5%368
8
Fatigue5.1%338
9
Death4.9%328
10
Blood Pressure Increased4.8%320
11
Headache3.6%240
12
Hypertension3.3%222
13
Nausea3.2%212
14
Product Prescribing Issue3.2%212
15
Dizziness2.9%195

These are voluntary reports and do not establish that fostamatinib caused these reactions.

Report severity

35.6%Serious2,374 reports
24.4%Hospitalizations1,624 reports
7.6%Fatal505 reports

Seriousness is determined by the reporter, not by OpenClaim.

Fostamatinib drug interactions

Other drugs that appear in adverse event reports alongside fostamatinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Romiplostim1.4%91
2
Rituximab1.1%73
3
Eltrombopag0.7%45
4
Prednisone0.5%36
5
Avatrombopag-maleate0.5%33
6
Prednisolone0.4%28
7
Dexamethasone0.4%27
8
Mycophenolate0.4%27
9
Efgartigimod0.3%19
10
Methotrexate0.2%13
11
Methylprednisolone0.2%13
12
Cyclophosphamide0.2%11
13
Cyclosporine0.2%10
14
Azathioprine0.1%9
15
Ibrutinib0.1%7

Taken alongside

1
Prednisone8.1%541
2
Ergocalciferol7.3%488
3
Amlodipine6.7%444
4
Metoprolol6.0%400
5
Levothyroxine-sodium5.9%394
6
Atorvastatin-calcium5.8%384
7
Eltrombopag5.2%344
8
Acetaminophen4.9%326
9
Romiplostim4.9%326
10
Losartan-potassium4.6%304
11
Omeprazole4.6%304
12
Cyanocobalamin4.4%295
13
Lisinopril4.0%265
14
Pantoprazole-sodium3.9%259
15
Furosemide3.5%234

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports fostamatinib side effects

54.4% of fostamatinib adverse event reports involve female patients and 35.5% involve male patients. The largest age group is elderly at 55%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.4%
Male35.5%
Unknown10.1%

Age group

< 20.0%
2–11<0.1%
12–170.4%
18–6444.2%
65+55.3%

What is fostamatinib used for

Conditions and purposes for which patients were taking fostamatinib when the adverse event was reported.

Abdominal PainAnaemiaAnaemia Vitamin B12 DeficiencyAntiphospholipid SyndromeAplastic AnaemiaArteriosclerosisArteriosclerosis Coronary ArteryAutoimmune DisorderAutoimmune Haemolytic AnaemiaAcute Myeloid LeukaemiaAdverse Drug ReactionAnaemiaAnaemia Vitamin B12 DeficiencyAntiphospholipid SyndromeAplastic Anaemia

Showing 15 of 174 indications

Fostamatinib brand names and reporting trend

Fostamatinib is sold under the brand name Tavalisse.

Brand names

Tavalisse704

Quarterly reports (20062025)

200620202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking fostamatinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.