OpenClaim

Fosnetupitant Side Effects

The most commonly reported side effects of fosnetupitant include nausea, diarrhoea, and fatigue, based on 1,396 FDA adverse event reports from 2015 to 2025.

Fosnetupitant side effects

Percentages show how often each reaction appears relative to total reports for fosnetupitant.

1
Nausea11.0%153
2
Diarrhoea8.3%116
3
Fatigue8.0%112
4
Neutropenia7.6%106
5
Dyspnoea6.8%95
6
Vomiting6.5%91
7
Death6.5%91
8
Off Label Use6.4%89
9
Pyrexia4.7%66
10
Constipation4.5%63
11
Thrombocytopenia4.4%62
12
Asthenia4.4%62
13
Febrile Neutropenia4.4%61
14
Hypotension4.4%61
15
Anaemia4.3%60

These are voluntary reports and do not establish that fosnetupitant caused these reactions.

Report severity

93.2%Serious1,301 reports
52.9%Hospitalizations738 reports
13.6%Fatal190 reports

Seriousness is determined by the reporter, not by OpenClaim.

Fosnetupitant drug interactions

Other drugs that appear in adverse event reports alongside fosnetupitant. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Netupitant29.6%413
2
Palonosetron-hydrochloride29.6%413
3
Carboplatin25.8%360
4
Paclitaxel14.8%207
5
Cyclophosphamide10.7%149
6
Atezolizumab8.8%123
7
Pemetrexed8.8%123
8
Dexamethasone8.3%116
9
Oxaliplatin8.2%115
10
Cisplatin7.7%108
11
Pembrolizumab7.7%107
12
Fluorouracil6.7%93
13
Epirubicin-hydrochloride6.4%90
14
Doxorubicin-hydrochloride6.2%87
15
Trastuzumab6.0%84

Taken alongside

1
Palonosetron-hydrochloride69.1%964
2
Netupitant69.0%963
3
Dexamethasone44.7%624
4
Acetaminophen15.3%213
5
Pantoprazole-sodium14.9%208
6
Pegfilgrastim13.0%182
7
Ondansetron11.7%163
8
Folic-acid10.6%148
9
Metoclopramide-hydrochloride9.1%127
10
Loperamide-hydrochloride7.4%103
11
Aspirin7.3%102
12
Methylprednisolone7.2%101
13
Levothyroxine-sodium6.9%96
14
Omeprazole6.7%93
15
Furosemide6.2%87

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports fosnetupitant side effects

60.2% of fosnetupitant adverse event reports involve female patients and 34.2% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.2%
Male34.2%
Unknown5.6%

Age group

< 20.0%
2–11<0.1%
12–170.4%
18–6457.7%
65+41.8%

What is fosnetupitant used for

Conditions and purposes for which patients were taking fosnetupitant when the adverse event was reported.

Anal CancerAntiemetic Supportive CareAntiemetic Supportive CareBladder CancerBrain Cancer MetastaticBrain Neoplasm MalignantBreast CancerBreast Cancer FemaleBreast Cancer Stage IBronchial CarcinomaBladder CancerBreast CancerBreast Cancer FemaleCervix NeoplasmChemotherapy

Showing 15 of 75 indications

Fosnetupitant brand names and reporting trend

Fosnetupitant is sold under the brand name Akynzeo.

Brand names

Akynzeo1

Quarterly reports (20152025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking fosnetupitant with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.