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Fosfomycin Side Effects

The most commonly reported side effects of fosfomycin include diarrhoea, off label use, and nausea, based on 3,715 FDA adverse event reports from 2004 to 2025.

Fosfomycin side effects

Percentages show how often each reaction appears relative to total reports for fosfomycin.

1
Diarrhoea16.3%605
2
Off Label Use15.3%570
3
Nausea14.1%525
4
Dyspnoea13.3%495
5
Malaise13.2%491
6
Fatigue13.2%490
7
Pyrexia13.1%487
8
Vomiting12.7%472
9
Dizziness12.4%461
10
Headache11.9%441
11
Pruritus11.5%426
12
Pain11.4%424
13
Arthralgia11.1%411
14
Covid-1911.0%409
15
Chest Pain10.3%384

These are voluntary reports and do not establish that fosfomycin caused these reactions.

Report severity

90.4%Serious3,357 reports
46.0%Hospitalizations1,709 reports
11.0%Fatal410 reports

Seriousness is determined by the reporter, not by OpenClaim.

Fosfomycin drug interactions

Other drugs that appear in adverse event reports alongside fosfomycin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Hydrochlorothiazide10.0%371
2
Cetirizine-hydrochloride9.7%362
3
Levothyroxine-sodium9.7%361
4
Apixaban9.7%359
5
Lansoprazole9.2%342
6
Dapagliflozin9.1%338
7
Bisoprolol-fumarate9.0%336
8
Naproxen9.0%335
9
Isosorbide9.0%333
10
Simvastatin8.9%330
11
Candesartan-cilexetil8.9%329
12
Digoxin8.9%329
13
Felodipine8.8%327
14
Linagliptin8.7%324
15
Omeprazole8.4%311

Taken alongside

1
Omeprazole15.7%583
2
Levothyroxine-sodium15.4%573
3
Acetaminophen14.2%527
4
Bisoprolol-fumarate13.8%512
5
Amitriptyline-hydrochloride10.8%400
6
Losartan-potassium10.1%375
7
Bendroflumethiazide9.1%338
8
Simvastatin8.4%311
9
Aspirin7.5%279
10
Lansoprazole7.5%277
11
Atorvastatin-calcium7.2%268
12
Pantoprazole-sodium6.9%255
13
Furosemide6.4%237
14
Amlodipine6.2%232
15
Albuterol5.7%212

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports fosfomycin side effects

56.9% of fosfomycin adverse event reports involve female patients and 27.9% involve male patients. The largest age group is adult at 49%. These figures reflect who reports side effects, not underlying risk.

Sex

Female56.9%
Male27.9%
Unknown15.2%

Age group

< 22.6%
2–111.4%
12–171.9%
18–6449.5%
65+44.6%

What is fosfomycin used for

Conditions and purposes for which patients were taking fosfomycin when the adverse event was reported.

Acinetobacter BacteraemiaAcinetobacter InfectionAcinetobacter Test PositiveAnti-infective TherapyAntibiotic ProphylaxisAntibiotic TherapyAntimicrobial Susceptibility TestArthritis InfectiveAspergillomaAsymptomatic BacteriuriaAbdominal AbscessAbdominal InfectionAbscessAcinetobacter BacteraemiaAcinetobacter Infection

Showing 15 of 306 indications

Fosfomycin brand names and reporting trend

Fosfomycin is sold under brand names including Fosfomycin Tromethamine, Contepo.

Brand names

Fosfomycin Tromethamine3,773
Contepo4

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking fosfomycin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.