OpenClaim

Fosaprepitant Side Effects

The most commonly reported side effects of fosaprepitant include nausea, dyspnoea, and pyrexia, based on 13,316 FDA adverse event reports from 2004 to 2025.

Fosaprepitant side effects

Percentages show how often each reaction appears relative to total reports for fosaprepitant.

1
Nausea9.3%1,245
2
Dyspnoea7.5%998
3
Pyrexia7.4%980
4
Diarrhoea7.2%955
5
Vomiting6.6%875
6
Fatigue6.5%859
7
Off Label Use6.0%794
8
Febrile Neutropenia5.6%743
9
Alopecia5.3%705
10
Rash5.2%686
11
Hypersensitivity4.9%659
12
Pruritus4.3%577
13
Decreased Appetite4.2%556
14
Stomatitis4.0%536
15
Infusion Related Reaction3.9%525

These are voluntary reports and do not establish that fosaprepitant caused these reactions.

Report severity

85.2%Serious11,339 reports
51.2%Hospitalizations6,823 reports
15.8%Fatal2,107 reports

Seriousness is determined by the reporter, not by OpenClaim.

Fosaprepitant drug interactions

Other drugs that appear in adverse event reports alongside fosaprepitant. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Aprepitant44.0%5,857
2
Carboplatin10.6%1,412
3
Cisplatin9.2%1,219
4
Fluorouracil7.9%1,055
5
Ondansetron7.8%1,037
6
Paclitaxel7.3%978
7
Prednisone7.1%949
8
Docetaxel7.0%931
9
Cyclophosphamide6.9%921
10
Oxaliplatin6.5%871
11
Doxorubicin-hydrochloride6.4%849
12
Bevacizumab6.0%797
13
Methylprednisolone5.9%780
14
Rituximab5.8%774
15
Acetaminophen5.5%738

Taken alongside

1
Aprepitant50.5%6,730
2
Dexamethasone32.8%4,361
3
Ondansetron23.3%3,099
4
Palonosetron-hydrochloride16.0%2,137
5
Acetaminophen14.3%1,906
6
Lorazepam9.1%1,213
7
Pantoprazole-sodium8.9%1,188
8
Granisetron7.7%1,025
9
Diphenhydramine7.5%997
10
Furosemide6.9%917
11
Pegfilgrastim6.7%894
12
Methylprednisolone6.3%845
13
Metoclopramide-hydrochloride6.3%839
14
Prochlorperazine6.3%839
15
Oxycodone5.3%711

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports fosaprepitant side effects

56.6% of fosaprepitant adverse event reports involve female patients and 35.0% involve male patients. The largest age group is adult at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female56.6%
Male35.0%
Unknown8.4%

Age group

< 20.6%
2–112.1%
12–172.1%
18–6461.6%
65+33.6%

What is fosaprepitant used for

Conditions and purposes for which patients were taking fosaprepitant when the adverse event was reported.

Abdominal DiscomfortAbdominal MigraineAbdominal PainAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Myeloid LeukaemiaAcute Promyelocytic LeukaemiaAdenocarcinomaAdenocarcinoma Of The CervixAdenocarcinoma PancreasAdjuvant TherapyAdverse Drug ReactionAdverse EventAdverse ReactionAmyloidosis

Showing 15 of 233 indications

Fosaprepitant brand names and reporting trend

Fosaprepitant is sold under the brand name Emend.

Brand names

Emend1,047

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking fosaprepitant with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.