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Fondaparinux Side Effects

The most commonly reported side effects of fondaparinux include off label use, haematoma, and anaemia, based on 9,978 FDA adverse event reports from 2004 to 2025. 1.9% of reports found the drug to be ineffective.

Fondaparinux side effects

Percentages show how often each reaction appears relative to total reports for fondaparinux.

1
Off Label Use5.1%513
2
Haematoma3.8%378
3
Anaemia3.7%373
4
Anaemia3.5%345
5
Haematoma2.9%290
6
Haemoglobin Decreased2.8%278
7
Pulmonary Embolism2.6%263
8
Pulmonary Embolism2.6%256
9
Haemorrhage2.6%255
10
Death2.1%209
11
Diarrhoea2.0%200
12
Deep Vein Thrombosis2.0%195
13
Drug Ineffective1.9%189
14
Drug Interaction1.9%187
15
Thrombosis1.8%184

These are voluntary reports and do not establish that fondaparinux caused these reactions.

Report severity

88.7%Serious8,851 reports
52.7%Hospitalizations5,254 reports
17.3%Fatal1,731 reports

Seriousness is determined by the reporter, not by OpenClaim.

Fondaparinux drug interactions

Other drugs that appear in adverse event reports alongside fondaparinux. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Aspirin4.4%436
2
Enoxaparin-sodium3.2%317
3
Warfarin2.5%253
4
Lenalidomide2.4%238
5
Heparin2.3%233
6
Gemfibrozil1.8%179
7
Clopidogrel-bisulfate1.7%169
8
Dexamethasone1.6%158
9
Rivaroxaban1.3%132
10
Bevacizumab1.2%119
11
Prednisone1.1%114
12
Amoxicillin1.1%112
13
Furosemide1.1%111
14
Capecitabine1.1%109
15
Rituximab1.1%106

Taken alongside

1
Acetaminophen9.6%960
2
Furosemide9.0%896
3
Aspirin8.2%818
4
Pantoprazole-sodium5.6%554
5
Levothyroxine-sodium5.4%536
6
Omeprazole5.2%522
7
Atorvastatin-calcium4.3%426
8
Oxycodone4.0%396
9
Prednisone4.0%396
10
Amlodipine3.9%394
11
Esomeprazole3.9%393
12
Bisoprolol-fumarate3.7%371
13
Metoprolol3.7%369
14
Ondansetron3.7%368
15
Warfarin3.6%357

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports fondaparinux side effects

49.0% of fondaparinux adverse event reports involve female patients and 38.6% involve male patients. The largest age group is elderly at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.0%
Male38.6%
Unknown12.4%

Age group

< 20.8%
2–110.4%
12–170.3%
18–6444.4%
65+54.1%

What is fondaparinux used for

Conditions and purposes for which patients were taking fondaparinux when the adverse event was reported.

Abdominal OperationAbortion SpontaneousAccidental ExposureAccidental Exposure To ProductAcute Coronary SyndromeAcute Myocardial InfarctionAdverse EventAnaemiaAngina PectorisAngina UnstableAngiodermatitisAngiopathyAngioplastyAnkle FractureAnkle Operation

Showing 15 of 365 indications

Fondaparinux brand names and reporting trend

Fondaparinux is sold under the brand name Fondaparinux Sodium.

Brand names

Fondaparinux Sodium3,108

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking fondaparinux with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.