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Follitropin Side Effects

The most commonly reported side effects of follitropin include ovarian hyperstimulation syndrome, no adverse event, and ascites, based on 3,711 FDA adverse event reports from 2004 to 2025. 3.9% of reports found the drug to be ineffective.

Follitropin side effects

Percentages show how often each reaction appears relative to total reports for follitropin.

1
Ovarian Hyperstimulation Syndrome18.4%684
2
No Adverse Event6.5%241
3
Ascites5.6%208
4
Abdominal Distension4.8%177
5
Headache4.6%172
6
Nausea4.0%150
7
Product Quality Issue3.9%145
8
Drug Ineffective3.9%143
9
Abdominal Pain3.2%120
10
Abortion Spontaneous2.9%109
11
Dyspnoea2.5%92
12
Incorrect Dose Administered2.5%92
13
Maternal Exposure During Pregnancy2.4%90
14
Fatigue2.3%86
15
Inappropriate Schedule Of Drug Administration2.3%85

These are voluntary reports and do not establish that follitropin caused these reactions.

Report severity

54.5%Serious2,023 reports
29.6%Hospitalizations1,100 reports
1.1%Fatal40 reports

Seriousness is determined by the reporter, not by OpenClaim.

Follitropin drug interactions

Other drugs that appear in adverse event reports alongside follitropin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ganirelix-acetate14.5%539
2
Menotropins-fsh8.9%329
3
Choriogonadotropin-alfa8.5%314
4
Gonadotropin-chorionic7.9%294
5
Progesterone6.8%251
6
Cetrorelix-acetate5.5%204
7
Leuprolide4.1%152
8
Estradiol2.7%102
9
Triptorelin-pamoate1.5%55
10
Letrozole1.4%53
11
Clomiphene-citrate1.1%39
12
Metformin0.9%33
13
Enoxaparin-sodium0.8%30
14
Nafarelin-acetate0.8%28
15
Urofollitropin0.7%26

Taken alongside

1
Menotropins-fsh19.0%705
2
Progesterone11.5%425
3
Ganirelix-acetate10.3%382
4
Leuprolide8.8%327
5
Estradiol7.8%291
6
Choriogonadotropin-alfa4.8%178
7
Azithromycin4.6%171
8
Doxycycline4.4%165
9
Gonadotropin-chorionic4.2%157
10
Levothyroxine-sodium4.1%154
11
Ethinyl-estradiol2.9%108
12
Aspirin2.5%92
13
Letrozole2.4%90
14
Ergocalciferol2.3%85
15
Metformin2.2%81

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports follitropin side effects

92.1% of follitropin adverse event reports involve female patients and 3.2% involve male patients. The largest age group is adult at 97%. These figures reflect who reports side effects, not underlying risk.

Sex

Female92.1%
Male3.2%
Unknown4.8%

Age group

< 21.9%
2–110.2%
12–170.4%
18–6497.3%
65+<0.1%

What is follitropin used for

Conditions and purposes for which patients were taking follitropin when the adverse event was reported.

AmenorrhoeaAnovulatory CycleAnti-muellerian Hormone Level DecreasedArtificial InseminationArtificial Insemination By DonorArtificial Insemination By PartnerAssisted FertilisationAssisted Reproductive TechnologyAzoospermiaAnovulatory CycleArtificial InseminationAssisted FertilisationAssisted Reproductive TechnologyAzoospermiaBlood Follicle Stimulating Hormone

Showing 15 of 107 indications

Follitropin brand names and reporting trend

Follitropin is sold under the brand name Gonal-f Rff.

Brand names

Gonal-f Rff408

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking follitropin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.