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Folic Side Effects

The most commonly reported side effects of folic include fatigue, pain, and arthralgia, based on 251,915 FDA adverse event reports from 2004 to 2025. 9.4% of reports found the drug to be ineffective.

Folic side effects

Percentages show how often each reaction appears relative to total reports for folic.

1
Drug Ineffective9.4%23,590
2
Fatigue8.7%21,945
3
Pain8.7%21,896
4
Arthralgia7.2%18,257
5
Off Label Use7.0%17,519
6
Rheumatoid Arthritis6.6%16,746
7
Nausea5.5%13,847
8
Diarrhoea5.1%12,916
9
Headache5.1%12,905
10
Rash5.0%12,717
11
Dyspnoea4.6%11,618
12
Abdominal Discomfort4.6%11,568
13
Alopecia4.5%11,461
14
Joint Swelling4.4%11,141
15
Condition Aggravated4.2%10,584

These are voluntary reports and do not establish that folic caused these reactions.

Report severity

73.8%Serious185,971 reports
36.2%Hospitalizations91,082 reports
9.1%Fatal23,022 reports

Seriousness is determined by the reporter, not by OpenClaim.

Folic drug interactions

Other drugs that appear in adverse event reports alongside folic. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab19.8%49,978
2
Methotrexate13.7%34,544
3
Etanercept12.1%30,373
4
Infliximab9.1%22,801
5
Rituximab7.8%19,607
6
Abatacept7.6%19,264
7
Tocilizumab7.4%18,679
8
Prednisone6.8%17,059
9
Leflunomide6.1%15,477
10
Certolizumab-pegol6.1%15,386
11
Hydroxychloroquine-sulfate6.1%15,300
12
Tofacitinib6.1%15,250
13
Golimumab5.3%13,272
14
Sulfasalazine5.1%12,961
15
Alendronate-sodium4.7%11,930

Taken alongside

1
Methotrexate30.2%75,964
2
Ergocalciferol19.3%48,679
3
Acetaminophen18.5%46,588
4
Prednisone16.5%41,605
5
Aspirin14.7%36,976
6
Omeprazole12.7%32,071
7
Levothyroxine-sodium12.5%31,603
8
Cyanocobalamin10.9%27,417
9
Pantoprazole-sodium10.1%25,408
10
Calcium9.8%24,721
11
Atorvastatin-calcium9.5%24,026
12
Furosemide9.1%22,832
13
Amlodipine8.5%21,451
14
Metoprolol8.0%20,089
15
Gabapentin7.9%19,906

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports folic side effects

62.9% of folic adverse event reports involve female patients and 29.6% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female62.9%
Male29.6%
Unknown7.5%

Age group

< 21.4%
2–111.0%
12–171.5%
18–6457.9%
65+38.2%

What is folic used for

Conditions and purposes for which patients were taking folic when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal InjuryAbdominal Pain UpperAbstains From AlcoholAcid Base Balance AbnormalAcidosisAcneAcquired Immunodeficiency SyndromeAcute Febrile Neutrophilic DermatosisAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RefractoryAcute Myeloid LeukaemiaAddison^s DiseaseAdenocarcinoma

Showing 15 of 1,508 indications

Folic brand names and reporting trend

Folic is sold under the brand name M.v.i.-12 Adult.

Brand names

M.v.i.-12 Adult306,108

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking folic with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.