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Fluticasone Side Effects

The most commonly reported side effects of fluticasone include dyspnoea, asthma, and cough, based on 350,715 FDA adverse event reports from 2004 to 2025. 7.8% of reports found the drug to be ineffective.

Fluticasone side effects

Percentages show how often each reaction appears relative to total reports for fluticasone.

1
Dyspnoea9.8%34,355
2
Drug Ineffective7.8%27,260
3
Asthma5.6%19,576
4
Cough5.2%18,084
5
Fatigue4.6%16,065
6
Pneumonia4.3%15,084
7
Headache4.2%14,555
8
Off Label Use4.0%13,990
9
Nausea3.7%12,923
10
Pain3.3%11,627
11
Malaise3.2%11,177
12
Diarrhoea3.1%10,788
13
Product Dose Omission Issue3.0%10,594
14
Wheezing3.0%10,429
15
Dizziness2.8%9,977

These are voluntary reports and do not establish that fluticasone caused these reactions.

Report severity

49.0%Serious171,893 reports
23.8%Hospitalizations83,362 reports
5.4%Fatal18,917 reports

Seriousness is determined by the reporter, not by OpenClaim.

Fluticasone drug interactions

Other drugs that appear in adverse event reports alongside fluticasone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Salmeterol-xinafoate16.9%59,203
2
Vilanterol-trifenatate13.6%47,856
3
Umeclidinium-bromide8.2%28,765
4
Albuterol5.8%20,235
5
Dupilumab4.1%14,258
6
Tiotropium-bromide3.3%11,628
7
Adalimumab2.4%8,527
8
Prednisone2.4%8,473
9
Omalizumab2.4%8,380
10
Lenalidomide2.3%7,934
11
Montelukast-sodium2.2%7,727
12
Sodium-oxybate2.2%7,675
13
Mepolizumab1.9%6,574
14
Budesonide1.9%6,497
15
Treprostinil1.6%5,688

Taken alongside

1
Albuterol28.3%99,085
2
Salmeterol-xinafoate20.0%70,076
3
Acetaminophen13.3%46,610
4
Montelukast-sodium13.0%45,702
5
Ergocalciferol12.5%43,963
6
Aspirin11.7%40,959
7
Omeprazole10.5%36,698
8
Levothyroxine-sodium10.1%35,318
9
Prednisone8.9%31,377
10
Furosemide8.7%30,524
11
Atorvastatin-calcium8.6%30,280
12
Gabapentin7.9%27,657
13
Vilanterol-trifenatate7.4%25,793
14
Cetirizine-hydrochloride7.2%25,296
15
Amlodipine6.9%24,232

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports fluticasone side effects

59.8% of fluticasone adverse event reports involve female patients and 31.5% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female59.8%
Male31.5%
Unknown8.6%

Age group

< 20.4%
2–113.1%
12–172.2%
18–6451.0%
65+43.3%

What is fluticasone used for

Conditions and purposes for which patients were taking fluticasone when the adverse event was reported.

AbasiaAbdominal DiscomfortAbuliaAccidentAccidental ExposureAccidental Exposure To ProductAcneAcquired Oesophageal WebAcute Graft Versus Host DiseaseAcute Myocardial InfarctionAcute Pulmonary HistoplasmosisAcute Respiratory Distress SyndromeAcute Respiratory FailureAcute SinusitisAddison^s Disease

Showing 15 of 1,454 indications

Fluticasone brand names and reporting trend

Fluticasone is sold under brand names including Flovent Hfa, Breo Ellipta.

Brand names

Flovent Hfa75,090
Breo Ellipta7,328

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking fluticasone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.