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Fluorescein Side Effects

The most commonly reported side effects of fluorescein include pruritus, nausea, and anaphylactic shock, based on 993 FDA adverse event reports from 2004 to 2025.

Fluorescein side effects

Percentages show how often each reaction appears relative to total reports for fluorescein.

1
Pruritus9.6%95
2
Nausea8.3%82
3
Anaphylactic Shock8.1%80
4
Rash7.6%75
5
Vomiting6.4%64
6
Dyspnoea5.8%58
7
Dizziness5.5%55
8
Loss Of Consciousness5.0%50
9
Chest Discomfort5.0%50
10
Urticaria4.4%44
11
Nausea4.3%43
12
Visual Acuity Reduced3.3%33
13
Loss Of Consciousness3.3%33
14
Dizziness2.9%29
15
Hyperhidrosis2.9%29

These are voluntary reports and do not establish that fluorescein caused these reactions.

Report severity

92.5%Serious919 reports
26.7%Hospitalizations265 reports
7.4%Fatal73 reports

Seriousness is determined by the reporter, not by OpenClaim.

Fluorescein drug interactions

Other drugs that appear in adverse event reports alongside fluorescein. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ranibizumab6.1%61
2
Verteporfin3.3%33
3
Tropicamide2.9%29
4
Aflibercept2.6%26
5
Indocyanine-green2.5%25
6
Metformin1.1%11
7
Amlodipine1.0%10
8
Dexamethasone1.0%10
9
Lidocaine1.0%10
10
Bevacizumab0.9%9
11
Acetaminophen0.9%9
12
Omeprazole0.8%8
13
Benoxinate-hydrochloride0.7%7
14
Labetalol-hydrochloride0.7%7
15
Amoxicillin0.7%7

Taken alongside

1
Aspirin5.1%51
2
Sodium-chloride3.8%38
3
Metformin2.8%28
4
Amlodipine2.8%28
5
Hydrochlorothiazide2.7%27
6
Tropicamide2.3%23
7
Simvastatin2.2%22
8
Insulin2.2%22
9
Atorvastatin-calcium2.1%21
10
Indocyanine-green2.1%21
11
Metoprolol1.9%19
12
Acetaminophen1.8%18
13
Ramipril1.7%17
14
Lisinopril1.7%17
15
Phenylephrine1.7%17

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports fluorescein side effects

43.9% of fluorescein adverse event reports involve female patients and 42.3% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female43.9%
Male42.3%
Unknown13.8%

Age group

< 21.2%
2–110.8%
12–172.8%
18–6452.7%
65+42.5%

What is fluorescein used for

Conditions and purposes for which patients were taking fluorescein when the adverse event was reported.

AngiogramAngiogram CerebralAngiogram NormalAngiogram RetinaAngiopathyAnxietyAge-related Macular DegenerationAnaesthesia EyeAngiogramAngiogram RetinaArterial Occlusive DiseaseCataractCerebrospinal Fluid LeakageChorioretinopathyContrast Media Reaction

Showing 15 of 112 indications

Fluorescein brand names and reporting trend

Fluorescein is sold under the brand name Funduscein-25.

Brand names

Funduscein-25509

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking fluorescein with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.