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Fluocinonide Side Effects

The most commonly reported side effects of fluocinonide include psoriasis, rash, and pruritus, based on 6,624 FDA adverse event reports from 2004 to 2025. 12.4% of reports found the drug to be ineffective.

Fluocinonide side effects

Percentages show how often each reaction appears relative to total reports for fluocinonide.

1
Drug Ineffective12.4%824
2
Psoriasis8.6%568
3
Rash7.0%464
4
Pruritus6.8%449
5
Off Label Use4.8%321
6
Fatigue4.6%308
7
Diarrhoea4.6%302
8
Nausea4.5%295
9
Pain4.4%290
10
Headache4.3%282
11
Arthralgia3.5%229
12
Product Use In Unapproved Indication3.3%217
13
Erythema2.9%191
14
Chronic Kidney Disease2.8%185
15
Dermatitis Atopic2.7%182

These are voluntary reports and do not establish that fluocinonide caused these reactions.

Report severity

46.3%Serious3,064 reports
20.2%Hospitalizations1,341 reports
5.0%Fatal333 reports

Seriousness is determined by the reporter, not by OpenClaim.

Fluocinonide drug interactions

Other drugs that appear in adverse event reports alongside fluocinonide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dupilumab12.0%793
2
Apremilast7.9%526
3
Adalimumab5.6%371
4
Clobetasol-propionate5.4%356
5
Triamcinolone4.5%300
6
Secukinumab4.4%290
7
Sodium-oxybate3.4%223
8
Methotrexate3.1%208
9
Etanercept3.1%206
10
Lenalidomide2.9%193
11
Omeprazole2.4%158
12
Esomeprazole2.2%145
13
Calcipotriene1.9%128
14
Prednisone1.9%126
15
Hydrocortisone1.9%125

Taken alongside

1
Acetaminophen19.1%1,268
2
Ergocalciferol18.3%1,212
3
Albuterol16.4%1,089
4
Triamcinolone15.7%1,038
5
Aspirin15.0%994
6
Fluticasone14.8%983
7
Clobetasol-propionate13.8%912
8
Omeprazole13.0%858
9
Levothyroxine-sodium12.7%843
10
Prednisone12.3%816
11
Atorvastatin-calcium11.7%775
12
Gabapentin11.3%750
13
Furosemide10.9%720
14
Metoprolol10.4%686
15
Amlodipine10.1%671

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports fluocinonide side effects

56.4% of fluocinonide adverse event reports involve female patients and 37.2% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female56.4%
Male37.2%
Unknown6.4%

Age group

< 2<0.1%
2–112.4%
12–172.6%
18–6458.4%
65+36.5%

What is fluocinonide used for

Conditions and purposes for which patients were taking fluocinonide when the adverse event was reported.

AcneAcute Graft Versus Host Disease In IntestineAllergy To ChemicalsAlopeciaAlopecia AreataAlopecia UniversalisAnaemiaAnal FissureAnal PruritusAnhidrosisAntiinflammatory TherapyArthralgiaArthropod BiteAsthmaAtrial Fibrillation

Showing 15 of 246 indications

Fluocinonide brand names and reporting trend

Fluocinonide is sold under the brand name Fluocinonide Emulsified Base.

Brand names

Fluocinonide Emulsified Base6,070

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking fluocinonide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.