OpenClaim

Flumazenil Side Effects

The most commonly reported side effects of flumazenil include intentional overdose, toxicity to various agents, and off label use, based on 951 FDA adverse event reports from 2004 to 2025. 9.1% of reports found the drug to be ineffective.

Flumazenil side effects

Percentages show how often each reaction appears relative to total reports for flumazenil.

1
Intentional Overdose10.3%98
2
Drug Ineffective9.1%87
3
Toxicity To Various Agents9.0%86
4
Off Label Use7.7%73
5
Product Use Issue6.5%62
6
Intentional Product Misuse6.4%61
7
Seizure5.9%56
8
Drug Dependence5.9%56
9
Coma5.5%52
10
Hypotension5.2%49
11
Depressed Level Of Consciousness4.5%43
12
Drug Withdrawal Convulsions4.5%43
13
Overdose3.6%34
14
Somnolence3.5%33
15
Pneumonia3.4%32

These are voluntary reports and do not establish that flumazenil caused these reactions.

Report severity

93.1%Serious885 reports
56.7%Hospitalizations539 reports
18.7%Fatal178 reports

Seriousness is determined by the reporter, not by OpenClaim.

Flumazenil drug interactions

Other drugs that appear in adverse event reports alongside flumazenil. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Diazepam12.2%116
2
Midazolam10.1%96
3
Clonazepam6.9%66
4
Propofol6.4%61
5
Fentanyl5.8%55
6
Naloxone-hydrochloride5.5%52
7
Lorazepam5.2%49
8
Quetiapine-fumarate4.4%42
9
Sodium-oxybate3.5%33
10
Epinephrine3.4%32
11
Levetiracetam3.4%32
12
Alprazolam3.2%30
13
Olanzapine2.7%26
14
Clobazam2.5%24
15
Acetaminophen2.3%22

Taken alongside

1
Midazolam18.0%171
2
Naloxone-hydrochloride15.7%149
3
Acetaminophen14.3%136
4
Fentanyl9.8%93
5
Lorazepam8.9%85
6
Ondansetron8.5%81
7
Sodium-chloride8.2%78
8
Lidocaine7.9%75
9
Aspirin7.4%70
10
Epinephrine7.2%68
11
Clonazepam7.0%67
12
Furosemide6.8%65
13
Pantoprazole-sodium6.6%63
14
Albuterol6.2%59
15
Diazepam6.2%59

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports flumazenil side effects

47.6% of flumazenil adverse event reports involve female patients and 43.1% involve male patients. The largest age group is adult at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.6%
Male43.1%
Unknown9.3%

Age group

< 21.5%
2–112.9%
12–172.4%
18–6462.9%
65+30.3%

What is flumazenil used for

Conditions and purposes for which patients were taking flumazenil when the adverse event was reported.

AgitationAlcohol Withdrawal SyndromeAltered State Of ConsciousnessAnaesthesiaAnaesthesia ReversalAnaesthetic PremedicationArgon Plasma CoagulationAtrial FibrillationAlcohol PoisoningAltered State Of ConsciousnessAnaesthesiaAnaesthesia ProcedureAnaesthesia ReversalAntipsychotic Drug Level Above TherapeuticB-cell Lymphoma

Showing 15 of 138 indications

Flumazenil brand names and reporting trend

Flumazenil is sold under the brand name Flumazenil.

Brand names

Flumazenil969

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking flumazenil with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.