OpenClaim

Fludrocortisone Side Effects

The most commonly reported side effects of fludrocortisone include dizziness, fatigue, and fall, based on 12,021 FDA adverse event reports from 2004 to 2025. 6.0% of reports found the drug to be ineffective.

Fludrocortisone side effects

Percentages show how often each reaction appears relative to total reports for fludrocortisone.

1
Dizziness6.3%762
2
Fatigue6.3%755
3
Fall6.1%737
4
Drug Ineffective6.0%720
5
Death5.3%638
6
Nausea5.1%609
7
Off Label Use4.6%553
8
Hypotension4.5%537
9
Headache4.2%510
10
Diarrhoea4.2%505
11
Asthenia3.8%456
12
Confusional State3.3%392
13
Pneumonia3.2%386
14
Malaise3.2%379
15
Vomiting3.1%377

These are voluntary reports and do not establish that fludrocortisone caused these reactions.

Report severity

73.7%Serious8,857 reports
40.6%Hospitalizations4,880 reports
13.1%Fatal1,570 reports

Seriousness is determined by the reporter, not by OpenClaim.

Fludrocortisone drug interactions

Other drugs that appear in adverse event reports alongside fludrocortisone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Droxidopa10.4%1,254
2
Levodopa5.9%708
3
Carbidopa5.7%688
4
Pimavanserin5.7%686
5
Hydrocortisone5.5%665
6
Lenalidomide3.9%464
7
Sodium-oxybate3.6%427
8
Dexamethasone2.3%273
9
Midodrine-hydrochloride2.0%242
10
Clozapine1.9%227
11
Prednisone1.5%178
12
Pantoprazole-sodium1.5%176
13
Pregabalin1.4%170
14
Furosemide1.3%153
15
Omeprazole1.2%147

Taken alongside

1
Levothyroxine-sodium18.7%2,250
2
Acetaminophen18.2%2,184
3
Midodrine-hydrochloride17.1%2,056
4
Ergocalciferol16.9%2,036
5
Hydrocortisone16.4%1,972
6
Aspirin15.9%1,912
7
Omeprazole13.2%1,591
8
Atorvastatin-calcium12.1%1,460
9
Carbidopa12.1%1,452
10
Gabapentin11.6%1,395
11
Levodopa10.8%1,304
12
Pantoprazole-sodium10.2%1,227
13
Prednisone10.0%1,207
14
Albuterol9.5%1,148
15
Ondansetron9.5%1,144

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports fludrocortisone side effects

47.4% of fludrocortisone adverse event reports involve female patients and 45.6% involve male patients. The largest age group is elderly at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.4%
Male45.6%
Unknown7.0%

Age group

< 21.1%
2–111.9%
12–172.5%
18–6442.6%
65+52.0%

What is fludrocortisone used for

Conditions and purposes for which patients were taking fludrocortisone when the adverse event was reported.

17-hydroxyprogesterone Increased21-hydroxylase Deficiency21-hydroxylase DeficiencyActh DecreasedActh-producing Pituitary TumourAcute Kidney InjuryAcute Lymphocytic LeukaemiaAddison's DiseaseAddison^s DiseaseAdrenal DisorderAdrenal Gland TuberculosisAdrenal HaemorrhageAdrenal InsufficiencyAdrenal Insufficiency NeonatalAdrenal Rest Tumour Of The Testis

Showing 15 of 354 indications

Fludrocortisone brand names and reporting trend

Fludrocortisone is sold under the brand name Fludrocortisone Acetate.

Brand names

Fludrocortisone Acetate10,174

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking fludrocortisone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.