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Floxuridine Side Effects

The most commonly reported side effects of floxuridine include hepatic steatosis, steatohepatitis, and diarrhoea, based on 156 FDA adverse event reports from 2004 to 2025. 10.3% of reports found the drug to be ineffective.

Floxuridine side effects

Percentages show how often each reaction appears relative to total reports for floxuridine.

1
Drug Ineffective10.3%16
2
Hepatic Steatosis8.3%13
3
Steatohepatitis7.7%12
4
Diarrhoea6.4%10
5
Alanine Aminotransferase Increased6.4%10
6
Diarrhoea5.8%9
7
Bone Marrow Failure4.5%7
8
Aspartate Aminotransferase Increased4.5%7
9
Abdominal Pain3.8%6
10
Death3.8%6
11
Nausea3.8%6
12
Off Label Use3.8%6
13
Neutropenia3.8%6
14
Dehydration3.2%5
15
Tachycardia3.2%5

These are voluntary reports and do not establish that floxuridine caused these reactions.

Report severity

94.2%Serious147 reports
35.3%Hospitalizations55 reports
17.9%Fatal28 reports

Seriousness is determined by the reporter, not by OpenClaim.

Floxuridine drug interactions

Other drugs that appear in adverse event reports alongside floxuridine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Oxaliplatin24.4%38
2
Fluorouracil19.9%31
3
Irinotecan-hydrochloride18.6%29
4
Bevacizumab13.5%21
5
Gemcitabine12.8%20
6
Leucovorin-calcium11.5%18
7
Docetaxel11.5%18
8
Cisplatin9.6%15
9
Dexamethasone9.0%14
10
Etoposide8.3%13
11
Methotrexate7.1%11
12
Levoleucovorin6.4%10
13
Cyclophosphamide6.4%10
14
Vincristine-sulfate6.4%10
15
Capecitabine5.8%9

Taken alongside

1
Oxaliplatin11.5%18
2
Dexamethasone10.9%17
3
Fluorouracil9.0%14
4
Levoleucovorin7.1%11
5
Irinotecan-hydrochloride5.8%9
6
Heparin5.1%8
7
Diphenhydramine4.5%7
8
Bevacizumab3.8%6
9
Cetuximab3.8%6
10
Filgrastim3.2%5
11
Atropine2.6%4
12
Pantoprazole-sodium2.6%4
13
Aprepitant2.6%4
14
Fosaprepitant-dimeglumine2.6%4
15
Palonosetron-hydrochloride2.6%4

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports floxuridine side effects

33.3% of floxuridine adverse event reports involve female patients and 37.2% involve male patients. The largest age group is adult at 72%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.3%
Male37.2%
Unknown29.5%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6472.2%
65+27.8%

What is floxuridine used for

Conditions and purposes for which patients were taking floxuridine when the adverse event was reported.

Adenocarcinoma GastricAdenocarcinoma Of ColonAdenocarcinoma Of ColonBreast CancerBreast Cancer In SituBreast Cancer RecurrentChemotherapyCholangiocarcinomaChoriocarcinomaColon CancerColon Cancer MetastaticColon Cancer Stage IiColon Cancer Stage IvColorectal CancerColorectal Cancer Metastatic

Showing 15 of 48 indications

Floxuridine brand names and reporting trend

Floxuridine is sold under the brand name Fudr.

Brand names

Fudr158

Quarterly reports (20042025)

2005201020152025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking floxuridine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.