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Flecainide Side Effects

The most commonly reported side effects of flecainide include atrial fibrillation, fatigue, and toxicity to various agents, based on 16,375 FDA adverse event reports from 2004 to 2025. 5.5% of reports found the drug to be ineffective.

Flecainide side effects

Percentages show how often each reaction appears relative to total reports for flecainide.

1
Atrial Fibrillation6.2%1,015
2
Drug Ineffective5.5%900
3
Fatigue4.9%799
4
Toxicity To Various Agents4.8%791
5
Dizziness4.2%685
6
Off Label Use4.2%685
7
Dyspnoea4.1%674
8
Nausea3.8%621
9
Drug Interaction3.4%558
10
Diarrhoea3.3%546
11
Headache3.3%543
12
Hypotension3.1%500
13
Asthenia2.8%455
14
Fall2.7%441
15
Malaise2.3%384

These are voluntary reports and do not establish that flecainide caused these reactions.

Report severity

77.5%Serious12,694 reports
40.9%Hospitalizations6,700 reports
9.3%Fatal1,523 reports

Seriousness is determined by the reporter, not by OpenClaim.

Flecainide drug interactions

Other drugs that appear in adverse event reports alongside flecainide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Apixaban5.5%897
2
Rivaroxaban4.6%750
3
Metoprolol3.7%599
4
Dabigatran-etexilate-mesylate3.4%560
5
Amiodarone-hydrochloride3.3%539
6
Lenalidomide3.2%532
7
Bisoprolol-fumarate2.3%369
8
Digoxin2.1%346
9
Adalimumab1.8%293
10
Sotalol-hydrochloride1.6%266
11
Propranolol-hydrochloride1.6%258
12
Furosemide1.6%256
13
Diltiazem1.5%245
14
Aspirin1.5%242
15
Warfarin1.4%222

Taken alongside

1
Metoprolol17.9%2,927
2
Levothyroxine-sodium12.4%2,025
3
Aspirin11.7%1,916
4
Apixaban11.3%1,853
5
Ergocalciferol10.2%1,669
6
Acetaminophen10.1%1,654
7
Atorvastatin-calcium9.9%1,620
8
Furosemide9.7%1,589
9
Omeprazole9.6%1,565
10
Diltiazem7.6%1,244
11
Amlodipine7.5%1,224
12
Warfarin6.9%1,136
13
Pantoprazole-sodium6.6%1,087
14
Albuterol6.5%1,067
15
Rivaroxaban5.9%963

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports flecainide side effects

55.2% of flecainide adverse event reports involve female patients and 37.3% involve male patients. The largest age group is elderly at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female55.2%
Male37.3%
Unknown7.5%

Age group

< 23.7%
2–111.1%
12–171.0%
18–6431.4%
65+62.8%

What is flecainide used for

Conditions and purposes for which patients were taking flecainide when the adverse event was reported.

Accessory Cardiac PathwayAdenomatous Polyposis ColiAdverse EventAgitationAllergy TestAnaesthesiaAnalgesiaAngina PectorisAnticoagulant TherapyAortic StenosisArrhythmiaArrhythmia ProphylaxisArrhythmia SupraventricularArrhythmogenic Right Ventricular DysplasiaArthritis

Showing 15 of 307 indications

Flecainide brand names and reporting trend

Flecainide is sold under the brand name Flecainide Acetate.

Brand names

Flecainide Acetate16,113

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking flecainide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.