OpenClaim

Filgrastim Side Effects

The most commonly reported side effects of filgrastim include febrile neutropenia, off label use, and neutropenia, based on 41,867 FDA adverse event reports from 2004 to 2025. 2.4% of reports found the drug to be ineffective.

Filgrastim side effects

Percentages show how often each reaction appears relative to total reports for filgrastim.

1
Febrile Neutropenia9.3%3,875
2
Off Label Use7.7%3,228
3
Neutropenia7.0%2,937
4
Death6.6%2,747
5
Pyrexia5.8%2,421
6
Diarrhoea4.8%2,026
7
Fatigue4.3%1,817
8
Nausea4.3%1,807
9
Pneumonia3.9%1,644
10
Thrombocytopenia3.8%1,607
11
Anaemia3.6%1,504
12
White Blood Cell Count Decreased3.1%1,303
13
Vomiting2.9%1,211
14
Sepsis2.9%1,210
15
Pancytopenia2.5%1,026

These are voluntary reports and do not establish that filgrastim caused these reactions.

Report severity

84.8%Serious35,500 reports
42.9%Hospitalizations17,970 reports
22.5%Fatal9,401 reports

Seriousness is determined by the reporter, not by OpenClaim.

Filgrastim drug interactions

Other drugs that appear in adverse event reports alongside filgrastim. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cyclophosphamide15.0%6,278
2
Doxorubicin-hydrochloride11.0%4,585
3
Vincristine-sulfate9.8%4,119
4
Rituximab9.8%4,111
5
Lenalidomide8.5%3,559
6
Dexamethasone7.9%3,316
7
Etoposide7.8%3,249
8
Prednisone7.6%3,184
9
Cytarabine6.7%2,823
10
Carboplatin4.8%2,024
11
Methotrexate4.8%1,995
12
Pegfilgrastim4.6%1,935
13
Fludarabine-phosphate4.4%1,861
14
Paclitaxel3.8%1,611
15
Docetaxel3.7%1,555

Taken alongside

1
Acetaminophen14.8%6,190
2
Dexamethasone14.8%6,186
3
Acyclovir14.1%5,899
4
Ondansetron13.4%5,624
5
Pantoprazole-sodium7.9%3,296
6
Furosemide7.2%3,012
7
Sulfamethoxazole7.2%3,008
8
Allopurinol6.9%2,876
9
Omeprazole6.8%2,852
10
Cyclophosphamide6.6%2,763
11
Aspirin6.6%2,746
12
Trimethoprim6.5%2,725
13
Fluconazole6.4%2,675
14
Lorazepam6.2%2,593
15
Metoclopramide-hydrochloride5.8%2,444

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports filgrastim side effects

44.5% of filgrastim adverse event reports involve female patients and 39.5% involve male patients. The largest age group is adult at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.5%
Male39.5%
Unknown16.1%

Age group

< 21.7%
2–115.0%
12–172.7%
18–6456.1%
65+34.5%

What is filgrastim used for

Conditions and purposes for which patients were taking filgrastim when the adverse event was reported.

5q Minus Syndrome5q Minus SyndromeAbdominal DistensionAbdominal InfectionAbdominal MassAbdominal PainAbortion SpontaneousAbscess LimbAcute LeukaemiaAcute LeukemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Monocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukaemia (in Remission)

Showing 15 of 1,019 indications

Filgrastim brand names and reporting trend

Filgrastim is sold under several brand names including Neupogen, Granix, Zarxio.

Brand names

Neupogen29,335
Granix48
Zarxio28
Nivestym7

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking filgrastim with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.