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Fexinidazole Side Effects

The most commonly reported side effects of fexinidazole include seizure, pyrexia, and asphyxia, based on 10 FDA adverse event reports from 2021 to 2025.

Fexinidazole side effects

Percentages show how often each reaction appears relative to total reports for fexinidazole.

1
Seizure40.0%4
2
Pyrexia40.0%4
3
Asphyxia20.0%2
4
Completed Suicide20.0%2
5
Abdominal Pain Upper20.0%2
6
Condition Aggravated20.0%2
7
Headache20.0%2
8
Constipation20.0%2
9
Flatulence10.0%1
10
Gastrointestinal Disorder10.0%1
11
Agitation10.0%1
12
Hyperhidrosis10.0%1
13
Coma10.0%1
14
Acute Pulmonary Oedema10.0%1
15
Ischaemic Stroke10.0%1

These are voluntary reports and do not establish that fexinidazole caused these reactions.

Report severity

100.0%Serious10 reports
40.0%Hospitalizations4 reports
90.0%Fatal9 reports

Seriousness is determined by the reporter, not by OpenClaim.

Fexinidazole drug interactions

Other drugs that appear in adverse event reports alongside fexinidazole. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Upadacitinib10.0%1

Taken alongside

1
Magnesium-hydroxide10.0%1
2
Metolazone10.0%1
3
Potassium-phosphate-monobasic10.0%1
4
Famotidine10.0%1
5
Torsemide10.0%1
6
Metformin10.0%1
7
Budesonide10.0%1
8
Desvenlafaxine10.0%1
9
Alprazolam10.0%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports fexinidazole side effects

10.0% of fexinidazole adverse event reports involve female patients and 70.0% involve male patients. The largest age group is adult at 100%. These figures reflect who reports side effects, not underlying risk.

Sex

Female10.0%
Male70.0%
Unknown20.0%

Age group

< 20.0%
2–110.0%
12–170.0%
18–64100.0%
65+0.0%

What is fexinidazole used for

Conditions and purposes for which patients were taking fexinidazole when the adverse event was reported.

African TrypanosomiasisHip ArthroplastyProduct Used For Unknown IndicationTrypanosomiasis

Fexinidazole brand names and reporting trend

Fexinidazole is sold under the brand name Fexinidazole.

Brand names

Fexinidazole12

Quarterly reports (20212025)

202120242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking fexinidazole with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.