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Ferric Oxyhydroxide Side Effects

The most commonly reported side effects of ferric oxyhydroxide include death, diarrhoea, and nausea, based on 2,959 FDA adverse event reports from 2014 to 2025.

Ferric Oxyhydroxide side effects

Percentages show how often each reaction appears relative to total reports for ferric oxyhydroxide.

1
Death38.7%1,146
2
Diarrhoea9.6%283
3
Nausea3.1%93
4
Hospitalisation2.9%85
5
Vomiting2.8%83
6
Constipation2.8%83
7
Faeces Discoloured2.7%79
8
Drug Intolerance2.2%64
9
Abdominal Discomfort2.0%58
10
Product Taste Abnormal1.9%57
11
Off Label Use1.7%51
12
Abdominal Pain1.7%50
13
End Stage Renal Disease1.7%50
14
Chronic Kidney Disease1.6%47
15
Pruritus1.5%44

These are voluntary reports and do not establish that ferric oxyhydroxide caused these reactions.

Report severity

74.0%Serious2,189 reports
18.7%Hospitalizations554 reports
44.2%Fatal1,307 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ferric Oxyhydroxide drug interactions

Other drugs that appear in adverse event reports alongside ferric oxyhydroxide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Tenapanor-hydrochloride2.5%74
2
Etelcalcetide2.1%63
3
Cinacalcet-hydrochloride2.0%60
4
Dextrose1.9%56
5
Iron1.8%53
6
Patiromer-sorbitex-calcium1.2%36
7
Methoxy-polyethylene-glycol-epoetin-beta1.0%31
8
Omeprazole0.9%28
9
Esomeprazole0.9%27
10
Tenofovir0.8%24
11
Ferric-citrate0.7%21
12
Lansoprazole0.7%21
13
Emtricitabine0.7%20
14
Darbepoetin-alfa0.6%17
15
Pantoprazole-sodium0.6%17

Taken alongside

1
Aspirin8.0%238
2
Sevelamer6.9%203
3
Amlodipine6.5%193
4
Atorvastatin-calcium5.8%171
5
Darbepoetin-alfa5.6%167
6
Calcitriol5.5%163
7
Furosemide5.3%157
8
Insulin4.9%146
9
Carvedilol4.9%144
10
Lanthanum-carbonate4.5%133
11
Cinacalcet-hydrochloride4.5%133
12
Nifedipine3.9%116
13
Metoprolol3.8%113
14
Acetaminophen3.8%112
15
Ergocalciferol3.6%108

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ferric oxyhydroxide side effects

34.4% of ferric oxyhydroxide adverse event reports involve female patients and 58.2% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female34.4%
Male58.2%
Unknown7.4%

Age group

< 20.0%
2–11<0.1%
12–170.2%
18–6450.7%
65+49.0%

What is ferric oxyhydroxide used for

Conditions and purposes for which patients were taking ferric oxyhydroxide when the adverse event was reported.

AnaemiaBlood PhosphorusBlood Phosphorus AbnormalBlood Phosphorus DecreasedBlood Phosphorus IncreasedBlood Potassium IncreasedBlood Pressure AbnormalBone DisorderBlood PhosphorusBlood Phosphorus AbnormalBlood Phosphorus DecreasedBlood Phosphorus IncreasedBlood Potassium IncreasedBlood Pressure MeasurementChronic Kidney Disease

Showing 15 of 55 indications

Ferric Oxyhydroxide brand names and reporting trend

Ferric Oxyhydroxide is sold under the brand name Velphoro.

Brand names

Velphoro180

Quarterly reports (20142025)

20142016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ferric oxyhydroxide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.