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Ferric Citrate Side Effects

The most commonly reported side effects of ferric citrate include diarrhoea, serum ferritin increased, and transferrin saturation increased, based on 2,688 FDA adverse event reports from 2004 to 2025. 2.8% of reports found the drug to be ineffective.

Ferric Citrate side effects

Percentages show how often each reaction appears relative to total reports for ferric citrate.

1
Diarrhoea11.6%312
2
Serum Ferritin Increased8.6%231
3
Transferrin Saturation Increased6.3%169
4
Death4.7%127
5
Faeces Discoloured4.5%120
6
Constipation3.6%96
7
Nausea3.0%81
8
Drug Ineffective2.8%75
9
Vomiting2.6%70
10
Chronic Kidney Disease2.4%65
11
Off Label Use2.4%64
12
Shunt Stenosis2.4%64
13
End Stage Renal Disease2.3%63
14
Pruritus2.3%62
15
Renal Failure2.0%54

These are voluntary reports and do not establish that ferric citrate caused these reactions.

Report severity

47.1%Serious1,265 reports
28.5%Hospitalizations766 reports
13.4%Fatal359 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ferric Citrate drug interactions

Other drugs that appear in adverse event reports alongside ferric citrate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Etelcalcetide5.3%143
2
Tenapanor-hydrochloride2.0%54
3
Patiromer-sorbitex-calcium1.8%49
4
Dextrose1.6%44
5
Omeprazole1.4%38
6
Esomeprazole1.3%35
7
Lenalidomide1.1%30
8
Lansoprazole1.0%27
9
Pantoprazole-sodium0.9%25
10
Darbepoetin-alfa0.7%20
11
Methoxy-polyethylene-glycol-epoetin-beta0.7%18
12
Tenofovir0.7%18
13
Vadadustat0.7%18
14
Treprostinil0.6%16
15
Daprodustat0.6%16

Taken alongside

1
Aspirin9.5%256
2
Amlodipine9.1%244
3
Carvedilol7.3%195
4
Atorvastatin-calcium7.1%190
5
Insulin7.0%189
6
Furosemide6.6%177
7
Calcitriol6.5%176
8
Ergocalciferol6.4%171
9
Lanthanum-carbonate6.2%166
10
Sevelamer5.8%155
11
Acetaminophen5.5%148
12
Darbepoetin-alfa5.2%141
13
Metoprolol5.1%137
14
Cinacalcet-hydrochloride4.9%132
15
Gabapentin4.3%116

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ferric citrate side effects

33.5% of ferric citrate adverse event reports involve female patients and 41.8% involve male patients. The largest age group is elderly at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.5%
Male41.8%
Unknown24.7%

Age group

< 20.1%
2–110.2%
12–170.4%
18–6447.6%
65+51.7%

What is ferric citrate used for

Conditions and purposes for which patients were taking ferric citrate when the adverse event was reported.

AnaemiaAnaemiaBlood Calcium IncreasedBlood IronBlood Iron DecreasedBlood PhosphorusBlood Phosphorus AbnormalBlood Phosphorus DecreasedBlood Phosphorus IncreasedBlood Potassium IncreasedBlood PhosphorusBlood Phosphorus AbnormalBlood Phosphorus DecreasedBlood Phosphorus IncreasedBlood Potassium Abnormal

Showing 15 of 63 indications

Ferric Citrate brand names and reporting trend

Ferric Citrate is sold under the brand name Auryxia.

Brand names

Auryxia772

Quarterly reports (20042025)

2004201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ferric citrate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.