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Fenoprofen Side Effects

The most commonly reported side effects of fenoprofen include drug hypersensitivity, chronic kidney disease, and pain, based on 176 FDA adverse event reports from 2004 to 2025. 2.8% of reports found the drug to be ineffective.

Fenoprofen side effects

Percentages show how often each reaction appears relative to total reports for fenoprofen.

1
Drug Hypersensitivity11.4%20
2
Chronic Kidney Disease6.8%12
3
Pain5.1%9
4
Fatigue4.5%8
5
Diarrhoea4.5%8
6
Headache4.5%8
7
Acute Kidney Injury4.5%8
8
Renal Failure4.0%7
9
Drug Interaction3.4%6
10
Therapy Cessation3.4%6
11
End Stage Renal Disease3.4%6
12
Arthralgia2.8%5
13
Chest Pain2.8%5
14
Drug Ineffective2.8%5
15
Insomnia2.8%5

These are voluntary reports and do not establish that fenoprofen caused these reactions.

Report severity

62.5%Serious110 reports
18.2%Hospitalizations32 reports
13.1%Fatal23 reports

Seriousness is determined by the reporter, not by OpenClaim.

Fenoprofen drug interactions

Other drugs that appear in adverse event reports alongside fenoprofen. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Naproxen11.4%20
2
Ibuprofen11.4%20
3
Diclofenac9.7%17
4
Piroxicam9.1%16
5
Sulindac8.0%14
6
Indomethacin8.0%14
7
Celecoxib8.0%14
8
Adalimumab7.4%13
9
Esomeprazole7.4%13
10
Acetaminophen6.8%12
11
Ketoprofen6.8%12
12
Etodolac6.3%11
13
Omeprazole6.3%11
14
Lansoprazole6.3%11
15
Flurbiprofen5.7%10

Taken alongside

1
Acetaminophen24.4%43
2
Aspirin18.2%32
3
Furosemide17.6%31
4
Levothyroxine-sodium16.5%29
5
Lisinopril12.5%22
6
Albuterol11.9%21
7
Gabapentin11.4%20
8
Naproxen11.4%20
9
Omeprazole10.8%19
10
Alprazolam10.8%19
11
Ergocalciferol10.8%19
12
Simvastatin10.8%19
13
Hydrochlorothiazide9.7%17
14
Fluticasone9.7%17
15
Hydrocodone9.1%16

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports fenoprofen side effects

67.0% of fenoprofen adverse event reports involve female patients and 20.5% involve male patients. The largest age group is adult at 68%. These figures reflect who reports side effects, not underlying risk.

Sex

Female67.0%
Male20.5%
Unknown12.5%

Age group

< 20.0%
2–110.0%
12–171.0%
18–6468.4%
65+30.6%

What is fenoprofen used for

Conditions and purposes for which patients were taking fenoprofen when the adverse event was reported.

Analgesic TherapyAnkle FractureArthritisArthropathyBone DisorderDrug Use For Unknown IndicationExostosisHeadacheInflammationLigament SprainMigraineNeck PainPainPlantar FasciitisProduct Used For Unknown Indication

Showing 15 of 23 indications

Fenoprofen brand names and reporting trend

Fenoprofen is sold under the brand name Nalfon.

Brand names

Nalfon128

Quarterly reports (20042025)

20042010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking fenoprofen with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.