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Fenoldopam Side Effects

The most commonly reported side effects of fenoldopam include renal failure, pain, and anxiety, based on 69 FDA adverse event reports from 2004 to 2025. 14.5% of reports found the drug to be ineffective.

Fenoldopam side effects

Percentages show how often each reaction appears relative to total reports for fenoldopam.

1
Renal Failure40.6%28
2
Pain39.1%27
3
Anxiety37.7%26
4
Fear36.2%25
5
Injury34.8%24
6
Unevaluable Event34.8%24
7
Emotional Distress31.9%22
8
Renal Injury30.4%21
9
Anhedonia27.5%19
10
Stress26.1%18
11
Renal Impairment24.6%17
12
Death15.9%11
13
Multi-organ Failure15.9%11
14
Drug Ineffective14.5%10
15
Depression13.0%9

These are voluntary reports and do not establish that fenoldopam caused these reactions.

Report severity

98.6%Serious68 reports
31.9%Hospitalizations22 reports
20.3%Fatal14 reports

Seriousness is determined by the reporter, not by OpenClaim.

Fenoldopam drug interactions

Other drugs that appear in adverse event reports alongside fenoldopam. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Aprotinin43.5%30
2
Nitroglycerin10.1%7
3
Sodium-nitroprusside10.1%7
4
Labetalol-hydrochloride7.2%5
5
Enalapril-maleate7.2%5
6
Amlodipine7.2%5
7
Gadopentetate-dimeglumine2.9%2
8
Gadodiamide2.9%2
9
Defibrotide-sodium2.9%2
10
Esmolol-hydrochloride2.9%2
11
Clevidipine2.9%2
12
Amiodarone-hydrochloride1.4%1
13
Iodixanol1.4%1
14
Heparin1.4%1
15
Enoxaparin-sodium1.4%1

Taken alongside

1
Furosemide49.3%34
2
Midazolam42.0%29
3
Heparin39.1%27
4
Fentanyl39.1%27
5
Nitroglycerin29.0%20
6
Protamine-sulfate27.5%19
7
Lidocaine26.1%18
8
Insulin24.6%17
9
Metoprolol21.7%15
10
Cefazolin-sodium21.7%15
11
Milrinone-lactate20.3%14
12
Amlodipine18.8%13
13
Potassium-chloride17.4%12
14
Epinephrine15.9%11
15
Mannitol15.9%11

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports fenoldopam side effects

30.4% of fenoldopam adverse event reports involve female patients and 60.9% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female30.4%
Male60.9%
Unknown8.7%

Age group

< 212.3%
2–113.5%
12–170.0%
18–6450.9%
65+33.3%

What is fenoldopam used for

Conditions and purposes for which patients were taking fenoldopam when the adverse event was reported.

Blood PressureBlood Pressure Inadequately ControlledBlood Pressure IncreasedCardiac ArrestDiuretic TherapyDyslipidaemiaGlomerular Filtration Rate DecreasedHypertensionHypertensionPeripheral Vascular DisorderProduct Used For Unknown IndicationProphylaxisPolyuriaRenal Failure ChronicRenal Vessel Disorder

Showing 15 of 16 indications

Fenoldopam brand names and reporting trend

Fenoldopam is sold under the brand name Fenoldopam Mesylate.

Brand names

Fenoldopam Mesylate2

Quarterly reports (20042025)

200520102025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking fenoldopam with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.