OpenClaim

Fenofibrate Side Effects

The most commonly reported side effects of fenofibrate include fatigue, diarrhoea, and nausea, based on 51,646 FDA adverse event reports from 2004 to 2025. 3.9% of reports found the drug to be ineffective.

Fenofibrate side effects

Percentages show how often each reaction appears relative to total reports for fenofibrate.

1
Fatigue4.6%2,376
2
Diarrhoea4.5%2,322
3
Nausea4.1%2,137
4
Drug Ineffective3.9%2,013
5
Headache3.2%1,640
6
Dyspnoea3.1%1,619
7
Pain3.0%1,553
8
Acute Kidney Injury3.0%1,550
9
Off Label Use3.0%1,524
10
Dizziness2.9%1,497
11
Chronic Kidney Disease2.9%1,477
12
Fall2.8%1,449
13
Asthenia2.7%1,386
14
Arthralgia2.4%1,253
15
Vomiting2.4%1,241

These are voluntary reports and do not establish that fenofibrate caused these reactions.

Report severity

65.8%Serious34,006 reports
33.6%Hospitalizations17,374 reports
7.3%Fatal3,757 reports

Seriousness is determined by the reporter, not by OpenClaim.

Fenofibrate drug interactions

Other drugs that appear in adverse event reports alongside fenofibrate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab4.4%2,257
2
Omeprazole3.5%1,833
3
Atorvastatin-calcium3.4%1,738
4
Esomeprazole2.9%1,514
5
Lenalidomide2.8%1,451
6
Metformin2.8%1,446
7
Niacin2.6%1,352
8
Rosuvastatin2.3%1,196
9
Exenatide-synthetic2.2%1,132
10
Pantoprazole-sodium2.1%1,105
11
Pregabalin2.1%1,093
12
Aspirin1.9%989
13
Hydrochlorothiazide1.8%951
14
Ezetimibe1.7%879
15
Acetaminophen1.7%868

Taken alongside

1
Aspirin23.8%12,269
2
Metformin21.1%10,916
3
Atorvastatin-calcium17.0%8,779
4
Levothyroxine-sodium16.2%8,373
5
Ergocalciferol14.2%7,330
6
Metoprolol14.1%7,276
7
Acetaminophen14.0%7,249
8
Lisinopril13.8%7,137
9
Insulin13.4%6,926
10
Amlodipine13.2%6,797
11
Omeprazole12.7%6,535
12
Furosemide12.0%6,210
13
Gabapentin10.4%5,380
14
Hydrochlorothiazide9.7%5,015
15
Simvastatin9.6%4,937

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports fenofibrate side effects

45.1% of fenofibrate adverse event reports involve female patients and 48.3% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female45.1%
Male48.3%
Unknown6.7%

Age group

< 20.2%
2–110.6%
12–170.5%
18–6454.0%
65+44.8%

What is fenofibrate used for

Conditions and purposes for which patients were taking fenofibrate when the adverse event was reported.

Abdominal PainAcute Fatty Liver Of PregnancyAcute Lymphocytic Leukaemia RecurrentAcute Myocardial InfarctionAdjuvant TherapyAffective DisorderAlveolar RhabdomyosarcomaAmnesiaAngina PectorisAnticoagulant TherapyAnxietyAppetite DisorderArrhythmiaArterial Occlusive DiseaseArteriosclerosis

Showing 15 of 450 indications

Fenofibrate brand names and reporting trend

Fenofibrate is sold under the brand name Fenoglide.

Brand names

Fenoglide35,800

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking fenofibrate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.