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Famotidine Side Effects

The most commonly reported side effects of famotidine include chronic kidney disease, fatigue, and nausea, based on 112,572 FDA adverse event reports from 2004 to 2025. 4.7% of reports found the drug to be ineffective.

Famotidine side effects

Percentages show how often each reaction appears relative to total reports for famotidine.

1
Chronic Kidney Disease6.3%7,132
2
Fatigue5.8%6,536
3
Nausea5.8%6,476
4
Diarrhoea5.2%5,874
5
Off Label Use5.1%5,708
6
Drug Ineffective4.7%5,258
7
Acute Kidney Injury4.4%4,978
8
Dyspnoea4.1%4,607
9
Headache4.0%4,553
10
Pain3.6%3,999
11
Renal Failure3.5%3,900
12
Vomiting3.4%3,816
13
Dizziness3.3%3,710
14
Death3.1%3,476
15
Pneumonia2.7%3,018

These are voluntary reports and do not establish that famotidine caused these reactions.

Report severity

65.8%Serious74,079 reports
32.9%Hospitalizations37,015 reports
9.5%Fatal10,686 reports

Seriousness is determined by the reporter, not by OpenClaim.

Famotidine drug interactions

Other drugs that appear in adverse event reports alongside famotidine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Omeprazole6.9%7,727
2
Esomeprazole6.3%7,045
3
Pantoprazole-sodium5.0%5,663
4
Lansoprazole5.0%5,591
5
Lenalidomide4.9%5,469
6
Dupilumab2.6%2,910
7
Treprostinil2.2%2,522
8
Adalimumab2.2%2,476
9
Dexlansoprazole2.0%2,235
10
Magnesium-hydroxide1.5%1,730
11
Dexamethasone1.5%1,705
12
Paclitaxel1.4%1,621
13
Pomalidomide1.4%1,566
14
Sodium-oxybate1.4%1,527
15
Calcium-carbonate1.3%1,492

Taken alongside

1
Acetaminophen23.6%26,538
2
Aspirin18.8%21,194
3
Ergocalciferol17.5%19,727
4
Albuterol13.7%15,463
5
Ondansetron13.5%15,153
6
Furosemide13.4%15,100
7
Atorvastatin-calcium13.4%15,045
8
Levothyroxine-sodium12.6%14,131
9
Amlodipine12.2%13,729
10
Gabapentin12.0%13,520
11
Metoprolol11.5%12,934
12
Diphenhydramine11.2%12,561
13
Prednisone11.0%12,419
14
Fluticasone10.6%11,901
15
Dexamethasone10.0%11,292

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports famotidine side effects

56.0% of famotidine adverse event reports involve female patients and 34.1% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female56.0%
Male34.1%
Unknown9.9%

Age group

< 21.1%
2–112.3%
12–171.8%
18–6451.5%
65+43.3%

What is famotidine used for

Conditions and purposes for which patients were taking famotidine when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal HerniaAbdominal OperationAbdominal PainAbdominal Pain UpperAbdominal SymptomAbdominal TendernessAbo IncompatibilityAccidental ExposureAccidental Exposure To ProductAccidental Exposure To Product By ChildAcid Base BalanceAcid Base Balance AbnormalAcid Peptic Disease

Showing 15 of 1,333 indications

Famotidine brand names and reporting trend

Famotidine is sold under the brand name Famotidine Preservative Free In Plastic Container.

Brand names

Famotidine Preservative Free In Plastic Container77,778

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking famotidine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.