OpenClaim

Ezogabine Side Effects

The most commonly reported side effects of ezogabine include urinary retention, convulsion, and chromaturia, based on 372 FDA adverse event reports from 2012 to 2025. 7.3% of reports found the drug to be ineffective.

Ezogabine side effects

Percentages show how often each reaction appears relative to total reports for ezogabine.

1
Urinary Retention17.2%64
2
Convulsion9.4%35
3
Drug Ineffective7.3%27
4
Chromaturia5.6%21
5
Seizure5.1%19
6
Convulsion4.0%15
7
Off Label Use3.8%14
8
Urinary Hesitation3.5%13
9
Rash3.5%13
10
Status Epilepticus3.2%12
11
Dysuria3.2%12
12
Somnolence3.0%11
13
Toxicity To Various Agents3.0%11
14
Urinary Tract Infection2.7%10
15
Confusional State2.7%10

These are voluntary reports and do not establish that ezogabine caused these reactions.

Report severity

64.5%Serious240 reports
17.7%Hospitalizations66 reports
3.0%Fatal11 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ezogabine drug interactions

Other drugs that appear in adverse event reports alongside ezogabine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lamotrigine9.7%36
2
Levetiracetam8.6%32
3
Topiramate5.6%21
4
Vigabatrin5.1%19
5
Pregabalin4.6%17
6
Lacosamide4.0%15
7
Phenytoin3.8%14
8
Clobazam3.0%11
9
Valproate-sodium2.7%10
10
Carbamazepine2.7%10
11
Zonisamide2.7%10
12
Diazepam2.4%9
13
Gabapentin2.2%8
14
Eslicarbazepine-acetate1.6%6
15
Perampanel1.6%6

Taken alongside

1
Levetiracetam15.6%58
2
Lacosamide12.4%46
3
Lamotrigine9.4%35
4
Oxcarbazepine9.4%35
5
Clobazam7.8%29
6
Carbamazepine7.3%27
7
Zonisamide6.7%25
8
Diazepam6.2%23
9
Phenytoin5.4%20
10
Lorazepam4.8%18
11
Divalproex-sodium4.6%17
12
Topiramate4.6%17
13
Clonazepam4.3%16
14
Felbamate3.8%14
15
Rufinamide3.5%13

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ezogabine side effects

43.3% of ezogabine adverse event reports involve female patients and 44.1% involve male patients. The largest age group is adult at 86%. These figures reflect who reports side effects, not underlying risk.

Sex

Female43.3%
Male44.1%
Unknown12.6%

Age group

< 20.5%
2–112.0%
12–176.1%
18–6485.7%
65+5.6%

What is ezogabine used for

Conditions and purposes for which patients were taking ezogabine when the adverse event was reported.

Amyotrophic Lateral SclerosisComplex Partial SeizuresConvulsionConvulsion ProphylaxisDystoniaEpilepsyEpilepsyGeneralised Tonic-clonic SeizureGeneralised Tonic-clonic SeizureInfantile SpasmsLennox-gastaut SyndromeNeonatal Epileptic SeizurePartial SeizuresPartial Seizures With Secondary GeneralisationPetit Mal Epilepsy

Showing 15 of 28 indications

Ezogabine brand names and reporting trend

Ezogabine is sold under the brand name Potiga.

Brand names

Potiga62

Quarterly reports (20122025)

20122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ezogabine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.