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Exenatide Side Effects

The most commonly reported side effects of exenatide include blood glucose increased, weight decreased, and nausea, based on 83,837 FDA adverse event reports from 2005 to 2025.

Exenatide side effects

Percentages show how often each reaction appears relative to total reports for exenatide.

1
Blood Glucose Increased16.5%13,868
2
Weight Decreased13.0%10,915
3
Nausea12.8%10,762
4
Injection Site Haemorrhage7.4%6,197
5
Injection Site Pain6.2%5,232
6
Decreased Appetite6.1%5,152
7
Device Leakage6.1%5,116
8
Blood Glucose Decreased6.0%4,993
9
Blood Glucose Increased5.4%4,486
10
Injection Site Mass4.6%3,825
11
Vomiting4.5%3,741
12
Weight Decreased4.3%3,617
13
Nausea4.0%3,346
14
Incorrect Dose Administered By Device4.0%3,334
15
Device Malfunction3.9%3,281

These are voluntary reports and do not establish that exenatide caused these reactions.

Report severity

24.6%Serious20,597 reports
11.7%Hospitalizations9,835 reports
2.6%Fatal2,218 reports

Seriousness is determined by the reporter, not by OpenClaim.

Exenatide drug interactions

Other drugs that appear in adverse event reports alongside exenatide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Metformin2.4%2,039
2
Lisinopril1.4%1,214
3
Insulin1.4%1,189
4
Sitagliptin1.2%1,029
5
Omeprazole0.9%776
6
Dapagliflozin0.9%739
7
Liraglutide0.8%692
8
Rosuvastatin0.7%628
9
Metoprolol0.6%544
10
Esomeprazole0.6%465
11
Pioglitazone-hydrochloride0.5%451
12
Dulaglutide0.3%212
13
Glimepiride0.2%200
14
Canagliflozin0.2%196
15
Atenolol0.2%191

Taken alongside

1
Metformin34.5%28,933
2
Insulin15.8%13,265
3
Glimepiride7.4%6,173
4
Glipizide7.3%6,130
5
Aspirin7.3%6,125
6
Pioglitazone-hydrochloride6.1%5,114
7
Glyburide5.6%4,683
8
Atorvastatin-calcium5.3%4,471
9
Rosiglitazone-maleate4.6%3,854
10
Lisinopril4.2%3,541
11
Levothyroxine-sodium4.1%3,446
12
Simvastatin4.1%3,397
13
Hydrochlorothiazide3.8%3,150
14
Furosemide3.2%2,677
15
Amlodipine3.1%2,630

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports exenatide side effects

58.6% of exenatide adverse event reports involve female patients and 38.0% involve male patients. The largest age group is adult at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female58.6%
Male38.0%
Unknown3.4%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6462.5%
65+37.4%

What is exenatide used for

Conditions and purposes for which patients were taking exenatide when the adverse event was reported.

Abdominal DistensionAccidental Needle StickAdjuvant TherapyAdverse Drug ReactionAdverse EventAdverse ReactionAlcoholismAmenorrhoeaAmnestic DisorderAnkylosing SpondylitisAnorexiaAppetite DisorderArthritisAsthmaAutoimmune Disorder

Showing 15 of 254 indications

Exenatide brand names and reporting trend

Exenatide is sold under the brand name Bydureon.

Brand names

Bydureon1,929

Quarterly reports (20052025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking exenatide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.