OpenClaim

Exemestane Side Effects

The most commonly reported side effects of exemestane include fatigue, malignant neoplasm progression, and diarrhoea, based on 21,959 FDA adverse event reports from 2004 to 2025.

Exemestane side effects

Percentages show how often each reaction appears relative to total reports for exemestane.

1
Fatigue9.5%2,087
2
Malignant Neoplasm Progression8.3%1,815
3
Diarrhoea7.4%1,633
4
Nausea7.4%1,616
5
Arthralgia6.6%1,453
6
Dyspnoea6.1%1,341
7
Asthenia4.8%1,052
8
Pain4.7%1,034
9
Malaise4.6%1,003
10
Headache4.5%986
11
Cough4.5%986
12
Vomiting4.3%940
13
Neoplasm Progression4.3%935
14
Disease Progression4.2%931
15
Death4.0%883

These are voluntary reports and do not establish that exemestane caused these reactions.

Report severity

76.8%Serious16,869 reports
25.5%Hospitalizations5,596 reports
11.8%Fatal2,586 reports

Seriousness is determined by the reporter, not by OpenClaim.

Exemestane drug interactions

Other drugs that appear in adverse event reports alongside exemestane. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Everolimus25.5%5,600
2
Letrozole11.5%2,531
3
Palbociclib9.8%2,162
4
Capecitabine7.5%1,637
5
Fulvestrant7.2%1,586
6
Anastrozole6.8%1,487
7
Zoledronic-acid6.6%1,452
8
Docetaxel6.4%1,415
9
Trastuzumab5.8%1,276
10
Tamoxifen-citrate5.8%1,273
11
Paclitaxel5.7%1,258
12
Denosumab4.3%938
13
Ribociclib3.7%811
14
Cyclophosphamide2.9%640
15
Pertuzumab2.6%570

Taken alongside

1
Acetaminophen7.3%1,600
2
Ergocalciferol6.8%1,489
3
Levothyroxine-sodium6.4%1,409
4
Calcium5.3%1,157
5
Omeprazole5.1%1,117
6
Aspirin5.0%1,099
7
Denosumab4.6%1,017
8
Furosemide4.1%900
9
Dexamethasone4.1%896
10
Letrozole4.0%868
11
Atorvastatin-calcium3.9%848
12
Fulvestrant3.8%824
13
Amlodipine3.7%817
14
Ondansetron3.6%801
15
Gabapentin3.6%796

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports exemestane side effects

91.1% of exemestane adverse event reports involve female patients and 1.0% involve male patients. The largest age group is elderly at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female91.1%
Male1.0%
Unknown7.9%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6448.5%
65+51.5%

What is exemestane used for

Conditions and purposes for which patients were taking exemestane when the adverse event was reported.

AbasiaAcute Myeloid LeukaemiaAdenocarcinomaAdjuvant TherapyAdrenal Gland CancerAdverse Drug ReactionAdverse EventAndrogen Replacement TherapyAntidepressant TherapyAntioestrogen TherapyAromatase Inhibition TherapyAssisted Reproductive TechnologyAsthmaAdenocarcinomaAdjuvant Therapy

Showing 15 of 342 indications

Exemestane brand names and reporting trend

Exemestane is sold under the brand name Aromasin.

Brand names

Aromasin14,148

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking exemestane with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.