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Evolocumab Side Effects

The most commonly reported side effects of evolocumab include device difficult to use, drug dose omission by device, and wrong technique in product usage process, based on 155,109 FDA adverse event reports from 2014 to 2025.

Evolocumab side effects

Percentages show how often each reaction appears relative to total reports for evolocumab.

1
Device Difficult To Use20.9%32,421
2
Drug Dose Omission By Device15.7%24,327
3
Wrong Technique In Product Usage Process14.1%21,879
4
Accidental Exposure To Product10.5%16,287
5
Injection Site Pain6.7%10,341
6
Product Storage Error4.3%6,630
7
Back Pain3.5%5,431
8
Myalgia3.4%5,267
9
Drug Dose Omission3.2%4,929
10
Injection Site Bruising2.9%4,557
11
Device Use Error2.6%4,051
12
Arthralgia2.5%3,922
13
Fatigue2.5%3,874
14
Injection Site Haemorrhage2.5%3,829
15
Off Label Use2.5%3,826

These are voluntary reports and do not establish that evolocumab caused these reactions.

Report severity

15.4%Serious23,869 reports
5.0%Hospitalizations7,692 reports
1.2%Fatal1,852 reports

Seriousness is determined by the reporter, not by OpenClaim.

Evolocumab drug interactions

Other drugs that appear in adverse event reports alongside evolocumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Alirocumab0.5%735
2
Rosuvastatin0.4%580
3
Atorvastatin-calcium0.3%489
4
Ezetimibe0.3%483
5
Erenumab-aooe0.3%454
6
Dupilumab0.2%338
7
Denosumab0.2%335
8
Etanercept0.2%277
9
Aspirin0.2%270
10
Simvastatin0.2%248
11
Lomitapide-mesylate0.1%214
12
Colesevelam-hydrochloride0.1%194
13
Apixaban0.1%184
14
Pravastatin-sodium0.1%169
15
Clopidogrel-bisulfate0.1%166

Taken alongside

1
Aspirin2.6%4,057
2
Ezetimibe1.7%2,669
3
Metoprolol1.4%2,208
4
Rosuvastatin1.3%2,020
5
Ergocalciferol1.3%2,018
6
Levothyroxine-sodium1.2%1,863
7
Amlodipine1.0%1,617
8
Atorvastatin-calcium1.0%1,572
9
Insulin1.0%1,537
10
Metformin0.8%1,286
11
Clopidogrel-bisulfate0.8%1,240
12
Losartan-potassium0.8%1,236
13
Lisinopril0.8%1,231
14
Pantoprazole-sodium0.8%1,213
15
Omeprazole0.8%1,171

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports evolocumab side effects

53.9% of evolocumab adverse event reports involve female patients and 38.7% involve male patients. The largest age group is elderly at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.9%
Male38.7%
Unknown7.4%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6436.7%
65+63.2%

What is evolocumab used for

Conditions and purposes for which patients were taking evolocumab when the adverse event was reported.

Abnormal Clotting FactorAccident At WorkAcquired Immunodeficiency SyndromeAcromegalyActinic KeratosisAcute Coronary SyndromeAcute Myocardial InfarctionAdverse Drug ReactionAdverse EventAdverse ReactionAmino Acid Metabolism DisorderAngina PectorisAngina UnstableAngiopathyAngioplasty

Showing 15 of 802 indications

Evolocumab brand names and reporting trend

Evolocumab is sold under the brand name Repatha.

Brand names

Repatha1,585

Quarterly reports (20142025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking evolocumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.