OpenClaim

Evinacumab Side Effects

The most commonly reported side effects of evinacumab include nausea, diarrhoea, and hepatic steatosis, based on 193 FDA adverse event reports from 2005 to 2025. 4.1% of reports found the drug to be ineffective.

Evinacumab side effects

Percentages show how often each reaction appears relative to total reports for evinacumab.

1
Nausea16.1%31
2
Diarrhoea15.0%29
3
Hepatic Steatosis12.4%24
4
International Normalised Ratio Increased9.8%19
5
Fatigue8.8%17
6
Product Dose Omission Issue7.8%15
7
Pain5.7%11
8
Dizziness5.2%10
9
Headache4.7%9
10
Pain In Extremity4.7%9
11
Off Label Use4.7%9
12
Hospitalisation4.1%8
13
Drug Ineffective4.1%8
14
Low Density Lipoprotein Increased3.6%7
15
Muscle Spasms3.6%7

These are voluntary reports and do not establish that evinacumab caused these reactions.

Report severity

57.5%Serious111 reports
21.2%Hospitalizations41 reports
6.2%Fatal12 reports

Seriousness is determined by the reporter, not by OpenClaim.

Evinacumab drug interactions

Other drugs that appear in adverse event reports alongside evinacumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lomitapide-mesylate25.9%50
2
Ezetimibe14.0%27
3
Rosuvastatin13.5%26
4
Atorvastatin-calcium13.0%25
5
Alirocumab8.8%17
6
Evolocumab1.6%3
7
Dipyridamole0.5%1
8
Nifedipine0.5%1
9
Adalimumab0.5%1
10
Simvastatin0.5%1
11
Dupilumab0.5%1

Taken alongside

1
Ezetimibe19.7%38
2
Atorvastatin-calcium10.4%20
3
Aspirin9.3%18
4
Rosuvastatin8.8%17
5
Evolocumab7.8%15
6
Metoprolol6.7%13
7
Furosemide5.7%11
8
Vitamin-e5.7%11
9
Nitroglycerin5.2%10
10
Ergocalciferol5.2%10
11
Gemfibrozil4.7%9
12
Amlodipine3.6%7
13
Acetaminophen3.1%6
14
Warfarin3.1%6
15
Fluticasone2.6%5

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports evinacumab side effects

56.0% of evinacumab adverse event reports involve female patients and 25.4% involve male patients. The largest age group is adult at 79%. These figures reflect who reports side effects, not underlying risk.

Sex

Female56.0%
Male25.4%
Unknown18.7%

Age group

< 20.0%
2–113.0%
12–174.5%
18–6479.1%
65+13.4%

What is evinacumab used for

Conditions and purposes for which patients were taking evinacumab when the adverse event was reported.

Blood CholesterolCrohn^s DiseaseHypercholesterolaemiaHypercholesterolaemiaHyperlipidaemiaLow Density Lipoprotein IncreasedProduct Used For Unknown IndicationPancreatitis AcuteProduct Used For Unknown IndicationType Iia HyperlipidaemiaType Iia Hyperlipidaemia

Evinacumab brand names and reporting trend

Evinacumab is sold under the brand name Evkeeza.

Brand names

Evkeeza132

Quarterly reports (20052025)

200520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking evinacumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.