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Everolimus Side Effects

The most commonly reported side effects of everolimus include death, malignant neoplasm progression, and diarrhoea, based on 50,769 FDA adverse event reports from 2004 to 2025. 4.4% of reports found the drug to be ineffective.

Everolimus side effects

Percentages show how often each reaction appears relative to total reports for everolimus.

1
Death11.5%5,856
2
Malignant Neoplasm Progression8.9%4,508
3
Diarrhoea7.5%3,813
4
Fatigue7.0%3,565
5
Stomatitis6.2%3,131
6
Nausea5.2%2,661
7
Dyspnoea4.6%2,339
8
Drug Ineffective4.4%2,232
9
Decreased Appetite3.9%1,997
10
Vomiting3.9%1,977
11
Rash3.8%1,916
12
Pyrexia3.7%1,875
13
Weight Decreased3.7%1,858
14
Malaise3.5%1,770
15
Cough3.4%1,750

These are voluntary reports and do not establish that everolimus caused these reactions.

Report severity

76.5%Serious38,821 reports
30.0%Hospitalizations15,238 reports
21.3%Fatal10,837 reports

Seriousness is determined by the reporter, not by OpenClaim.

Everolimus drug interactions

Other drugs that appear in adverse event reports alongside everolimus. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Exemestane6.5%3,286
2
Tacrolimus6.4%3,261
3
Lenvatinib-mesylate6.4%3,245
4
Mycophenolate4.3%2,203
5
Octreotide-acetate3.6%1,832
6
Letrozole2.8%1,430
7
Capecitabine2.5%1,271
8
Fulvestrant2.5%1,250
9
Prednisolone2.5%1,249
10
Cyclosporine2.4%1,197
11
Prednisone2.1%1,073
12
Paclitaxel1.9%974
13
Zoledronic-acid1.6%789
14
Palbociclib1.5%767
15
Methylprednisolone1.3%639

Taken alongside

1
Exemestane5.8%2,952
2
Acetaminophen3.7%1,856
3
Levothyroxine-sodium3.5%1,763
4
Amlodipine3.2%1,633
5
Ergocalciferol3.2%1,629
6
Aspirin2.6%1,340
7
Omeprazole2.5%1,283
8
Prednisone2.5%1,279
9
Oxycodone2.5%1,278
10
Ondansetron2.3%1,192
11
Furosemide2.2%1,101
12
Metoprolol2.1%1,046
13
Atorvastatin-calcium2.0%1,021
14
Insulin1.9%966
15
Calcium1.9%962

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports everolimus side effects

54.5% of everolimus adverse event reports involve female patients and 37.0% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.5%
Male37.0%
Unknown8.5%

Age group

< 20.8%
2–113.8%
12–172.5%
18–6456.7%
65+36.2%

What is everolimus used for

Conditions and purposes for which patients were taking everolimus when the adverse event was reported.

Abdominal DistensionAbdominal NeoplasmAcneAcoustic NeuromaAcromegalyAcute Coronary SyndromeAcute Graft Versus Host DiseaseAcute Graft Versus Host Disease In IntestineAcute Kidney InjuryAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Monocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukemia

Showing 15 of 1,222 indications

Everolimus brand names and reporting trend

Everolimus is sold under the brand name Afinitor Disperz.

Brand names

Afinitor Disperz21,081

Quarterly reports (20042025)

20042010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking everolimus with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.