OpenClaim

Etrasimod Side Effects

The most commonly reported side effects of etrasimod include condition aggravated, headache, and dizziness, based on 1,490 FDA adverse event reports from 2022 to 2025. 19.7% of reports found the drug to be ineffective.

Etrasimod side effects

Percentages show how often each reaction appears relative to total reports for etrasimod.

1
Drug Ineffective19.7%294
2
Condition Aggravated11.4%170
3
Headache5.8%86
4
Dizziness5.6%84
5
Colitis Ulcerative5.3%79
6
Fatigue4.8%71
7
Diarrhoea4.7%70
8
Type 2 Diabetes Mellitus4.4%66
9
Nausea3.8%56
10
Malaise3.6%54
11
Diabetic Eye Disease3.5%52
12
Haematochezia3.3%49
13
Colitis3.0%45
14
Abdominal Pain3.0%44
15
Off Label Use2.5%37

These are voluntary reports and do not establish that etrasimod caused these reactions.

Report severity

37.4%Serious558 reports
7.7%Hospitalizations115 reports
0.1%Fatal2 reports

Seriousness is determined by the reporter, not by OpenClaim.

Etrasimod drug interactions

Other drugs that appear in adverse event reports alongside etrasimod. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab1.1%16
2
Vedolizumab0.9%14
3
Infliximab0.8%12
4
Mesalamine0.7%11
5
Ustekinumab0.5%8
6
Prednisolone0.5%8
7
Prednisone0.5%8
8
Ciprofloxacin0.5%7
9
Metronidazole0.5%7
10
Thioguanine0.5%7
11
Azathioprine0.3%5
12
Escitalopram-oxalate0.3%5
13
Upadacitinib0.3%4
14
Budesonide0.3%4
15
Dupilumab0.3%4

Taken alongside

1
Mesalamine3.6%53
2
Prednisone2.6%38
3
Budesonide1.5%23
4
Ergocalciferol1.0%15
5
Vedolizumab0.9%14
6
Ustekinumab0.8%12
7
Azathioprine0.6%9
8
Loperamide-hydrochloride0.6%9
9
Omeprazole0.6%9
10
Fluticasone0.6%9
11
Levothyroxine-sodium0.6%9
12
Pantoprazole-sodium0.5%8
13
Amlodipine0.5%8
14
Atorvastatin-calcium0.5%8
15
Albuterol0.5%7

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports etrasimod side effects

48.9% of etrasimod adverse event reports involve female patients and 42.0% involve male patients. The largest age group is adult at 85%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.9%
Male42.0%
Unknown9.1%

Age group

< 2<0.1%
2–110.0%
12–170.5%
18–6485.2%
65+14.2%

What is etrasimod used for

Conditions and purposes for which patients were taking etrasimod when the adverse event was reported.

Abdominal DistensionAbdominal PainAbdominal Pain LowerAnaemiaAnorectal DisorderArthritisAutoimmune DisorderAutoimmune PancreatitisCholangitis SclerosingClostridium Difficile ColitisColitisColitis MicroscopicColitis UlcerativeColon CancerConstipation

Showing 15 of 42 indications

Etrasimod brand names and reporting trend

Etrasimod is sold under the brand name Velsipity.

Brand names

Velsipity61

Quarterly reports (20222025)

202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking etrasimod with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.