OpenClaim

Etonogestrel Side Effects

The most commonly reported side effects of etonogestrel include no adverse event, product quality issue, and complication associated with device, based on 79,766 FDA adverse event reports from 2004 to 2025.

Etonogestrel side effects

Percentages show how often each reaction appears relative to total reports for etonogestrel.

1
No Adverse Event15.7%12,485
2
Product Quality Issue8.2%6,530
3
Complication Associated With Device7.7%6,141
4
Device Breakage7.3%5,853
5
Device Difficult To Use7.1%5,684
6
Unintended Pregnancy6.6%5,231
7
Incorrect Product Administration Duration5.3%4,213
8
Device Deployment Issue5.1%4,085
9
Pregnancy With Implant Contraceptive4.8%3,794
10
Device Expulsion4.6%3,709
11
Complication Of Device Removal4.6%3,707
12
Complication Of Device Insertion4.4%3,509
13
Menorrhagia4.3%3,467
14
Device Dislocation4.2%3,379
15
Incorrect Drug Administration Duration4.0%3,221

These are voluntary reports and do not establish that etonogestrel caused these reactions.

Report severity

35.4%Serious28,263 reports
10.8%Hospitalizations8,638 reports
0.6%Fatal460 reports

Seriousness is determined by the reporter, not by OpenClaim.

Etonogestrel drug interactions

Other drugs that appear in adverse event reports alongside etonogestrel. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ethinyl-estradiol24.6%19,621
2
Sodium-oxybate0.9%733
3
Levonorgestrel0.5%368
4
Adalimumab0.4%294
5
Dupilumab0.3%256
6
Isotretinoin0.2%163
7
Lamotrigine0.2%144
8
Ibuprofen0.2%123
9
Drospirenone0.1%116
10
Treprostinil0.1%88
11
Apremilast0.1%85
12
Sertraline-hydrochloride0.1%82
13
Fingolimod0.1%80
14
Infliximab<0.1%79
15
Topiramate<0.1%77

Taken alongside

1
Ethinyl-estradiol3.7%2,975
2
Acetaminophen1.8%1,441
3
Ibuprofen1.5%1,225
4
Albuterol1.5%1,173
5
Ergocalciferol1.1%914
6
Sertraline-hydrochloride1.0%815
7
Levothyroxine-sodium0.9%754
8
Fluticasone0.8%664
9
Cetirizine-hydrochloride0.8%651
10
Dextroamphetamine0.8%647
11
Omeprazole0.8%641
12
Amphetamine0.8%616
13
Bupropion0.7%561
14
Fluoxetine-hydrochloride0.7%544
15
Escitalopram-oxalate0.7%527

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports etonogestrel side effects

95.1% of etonogestrel adverse event reports involve female patients and 0.4% involve male patients. The largest age group is adult at 90%. These figures reflect who reports side effects, not underlying risk.

Sex

Female95.1%
Male0.4%
Unknown4.6%

Age group

< 20.3%
2–11<0.1%
12–179.4%
18–6490.1%
65+0.2%

What is etonogestrel used for

Conditions and purposes for which patients were taking etonogestrel when the adverse event was reported.

Abdominal PainAbdominal Pain UpperAbnormal Uterine BleedingAbnormal Withdrawal BleedingAccidental ExposureAcneAcne CysticAdenomyosisAdnexa Uteri PainAdverse EventAffective DisorderAlopeciaAmenorrhoeaAnaemiaAnalgesic Therapy

Showing 15 of 334 indications

Etonogestrel brand names and reporting trend

Etonogestrel is sold under the brand name Eluryng.

Brand names

Eluryng3,081

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking etonogestrel with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.