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Etodolac Side Effects

The most commonly reported side effects of etodolac include pain, arthralgia, and fatigue, based on 7,604 FDA adverse event reports from 2004 to 2025. 4.6% of reports found the drug to be ineffective.

Etodolac side effects

Percentages show how often each reaction appears relative to total reports for etodolac.

1
Drug Ineffective4.6%347
2
Pain4.2%320
3
Arthralgia3.8%287
4
Fatigue3.4%256
5
Nausea3.1%233
6
Drug Hypersensitivity3.0%225
7
Headache2.9%220
8
Diarrhoea2.7%207
9
Nausea2.5%187
10
Chronic Kidney Disease2.4%181
11
Rash2.2%169
12
Fall2.1%163
13
Acute Kidney Injury2.1%160
14
Dizziness2.1%157
15
Pain In Extremity2.0%155

These are voluntary reports and do not establish that etodolac caused these reactions.

Report severity

64.1%Serious4,872 reports
32.5%Hospitalizations2,469 reports
7.6%Fatal576 reports

Seriousness is determined by the reporter, not by OpenClaim.

Etodolac drug interactions

Other drugs that appear in adverse event reports alongside etodolac. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab11.6%884
2
Etanercept6.2%469
3
Sodium-oxybate3.5%264
4
Esomeprazole2.6%199
5
Omeprazole2.5%193
6
Methotrexate2.3%176
7
Pregabalin2.2%171
8
Infliximab2.2%168
9
Apremilast2.0%150
10
Tofacitinib1.8%137
11
Acetaminophen1.8%135
12
Celecoxib1.7%133
13
Ibuprofen1.7%132
14
Pantoprazole-sodium1.7%130
15
Quetiapine-fumarate1.7%128

Taken alongside

1
Acetaminophen18.0%1,368
2
Omeprazole13.8%1,050
3
Aspirin13.5%1,028
4
Gabapentin12.3%932
5
Folic-acid11.9%908
6
Methotrexate11.5%876
7
Ergocalciferol11.4%870
8
Levothyroxine-sodium11.2%851
9
Tramadol-hydrochloride10.3%782
10
Prednisone10.2%778
11
Lisinopril9.9%755
12
Hydrocodone9.9%749
13
Hydrochlorothiazide8.6%651
14
Albuterol8.5%648
15
Amlodipine8.5%643

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports etodolac side effects

64.4% of etodolac adverse event reports involve female patients and 31.8% involve male patients. The largest age group is adult at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female64.4%
Male31.8%
Unknown3.8%

Age group

< 2<0.1%
2–11<0.1%
12–170.4%
18–6463.3%
65+36.2%

What is etodolac used for

Conditions and purposes for which patients were taking etodolac when the adverse event was reported.

Abdominal Pain UpperAbnormal BehaviourAcneAdenosquamous Cell Lung CancerAdverse Drug ReactionAdverse EventAffective DisorderAllergy TestAnalgesiaAnalgesic EffectAnalgesic Intervention Supportive TherapyAnalgesic TherapyAngina PectorisAnkylosing SpondylitisAntiinflammatory Therapy

Showing 15 of 269 indications

Etodolac brand names and reporting trend

Etodolac is sold under the brand name Lodine.

Brand names

Lodine6,404

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking etodolac with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.