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Ethynodiol Side Effects

The most commonly reported side effects of ethynodiol include nausea, nausea, and headache, based on 345 FDA adverse event reports from 2004 to 2025. 5.8% of reports found the drug to be ineffective.

Ethynodiol side effects

Percentages show how often each reaction appears relative to total reports for ethynodiol.

1
Drug Ineffective5.8%20
2
Nausea5.8%20
3
Nausea5.5%19
4
Headache4.1%14
5
Vomiting3.8%13
6
Anxiety3.8%13
7
Cough3.5%12
8
Malaise3.2%11
9
Feeling Abnormal3.2%11
10
Migraine2.9%10
11
Rash2.9%10
12
Fatigue2.9%10
13
Anxiety2.6%9
14
Diarrhoea2.6%9
15
Depression2.6%9

These are voluntary reports and do not establish that ethynodiol caused these reactions.

Report severity

50.4%Serious174 reports
17.4%Hospitalizations60 reports
1.2%Fatal4 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ethynodiol drug interactions

Other drugs that appear in adverse event reports alongside ethynodiol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ethinyl-estradiol20.6%71
2
Sodium-oxybate16.8%58
3
Adalimumab8.7%30
4
Drospirenone6.7%23
5
Isotretinoin4.9%17
6
Interferon3.8%13
7
Azithromycin2.3%8
8
Omalizumab2.0%7
9
Norethindrone1.7%6
10
Medroxyprogesterone-acetate1.7%6
11
Sertraline-hydrochloride1.4%5
12
Levonorgestrel1.4%5
13
Certolizumab-pegol1.4%5
14
Pantoprazole-sodium1.4%5
15
Fluticasone1.2%4

Taken alongside

1
Ethinyl-estradiol82.3%284
2
Acetaminophen14.2%49
3
Levothyroxine-sodium11.3%39
4
Albuterol11.0%38
5
Hydrocodone10.4%36
6
Ibuprofen10.1%35
7
Cetirizine-hydrochloride9.3%32
8
Ergocalciferol8.4%29
9
Clonazepam7.5%26
10
Prednisone7.5%26
11
Montelukast-sodium7.2%25
12
Escitalopram-oxalate7.0%24
13
Dextroamphetamine7.0%24
14
Aspirin6.7%23
15
Fluticasone6.4%22

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ethynodiol side effects

95.9% of ethynodiol adverse event reports involve female patients and 1.7% involve male patients. The largest age group is adult at 96%. These figures reflect who reports side effects, not underlying risk.

Sex

Female95.9%
Male1.7%
Unknown2.3%

Age group

< 20.0%
2–110.0%
12–172.5%
18–6495.5%
65+2.0%

What is ethynodiol used for

Conditions and purposes for which patients were taking ethynodiol when the adverse event was reported.

Blood Cholesterol IncreasedContraceptionCoughDepressionDrug Use For Unknown IndicationEndometriosisGallbladder DisorderHaemorrhageHirsutismHormone Level AbnormalHormone Replacement TherapyHormone TherapyIll-defined DisorderMenorrhagiaMenstrual Disorder

Showing 15 of 26 indications

Ethynodiol brand names and reporting trend

Ethynodiol is sold under the brand name Demulen 1/35-28.

Brand names

Demulen 1/35-283

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ethynodiol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.