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Ethionamide Side Effects

The most commonly reported side effects of ethionamide include drug resistance, vomiting, and nausea, based on 1,051 FDA adverse event reports from 2004 to 2025. 4.1% of reports found the drug to be ineffective.

Ethionamide side effects

Percentages show how often each reaction appears relative to total reports for ethionamide.

1
Drug Resistance12.0%126
2
Vomiting10.2%107
3
Nausea9.0%95
4
Anaemia8.3%87
5
Off Label Use8.1%85
6
Electrocardiogram Qt Prolonged7.3%77
7
Neuropathy Peripheral6.7%70
8
Tuberculosis5.5%58
9
Drug Reaction With Eosinophilia And Systemic Symptoms5.4%57
10
Treatment Failure4.9%52
11
Diarrhoea4.7%49
12
Drug Ineffective4.1%43
13
Decreased Appetite4.0%42
14
Arthralgia3.9%41
15
Pyrexia3.6%38

These are voluntary reports and do not establish that ethionamide caused these reactions.

Report severity

96.8%Serious1,017 reports
38.2%Hospitalizations401 reports
20.4%Fatal214 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ethionamide drug interactions

Other drugs that appear in adverse event reports alongside ethionamide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pyrazinamide44.1%464
2
Linezolid42.0%441
3
Levofloxacin35.4%372
4
Clofazimine34.9%367
5
Cycloserine34.6%364
6
Bedaquiline-fumarate32.6%343
7
Isoniazid30.7%323
8
Ethambutol-hydrochloride29.6%311
9
Aminosalicylic20.0%210
10
Moxifloxacin-hydrochloride19.5%205
11
Amikacin-sulfate10.7%112
12
Rifampin9.9%104
13
Kanamycin-sulfate9.9%104
14
Streptomycin-sulfate9.1%96
15
Capreomycin-sulfate8.8%93

Taken alongside

1
Pyrazinamide20.1%211
2
Pyridoxine19.9%209
3
Ethambutol-hydrochloride16.2%170
4
Cycloserine11.7%123
5
Isoniazid10.8%113
6
Kanamycin-sulfate10.3%108
7
Moxifloxacin-hydrochloride7.4%78
8
Amikacin-sulfate7.4%78
9
Clofazimine6.7%70
10
Ofloxacin6.6%69
11
Levofloxacin6.1%64
12
Omeprazole5.9%62
13
Linezolid5.6%59
14
Tenofovir4.9%52
15
Lamivudine4.8%50

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ethionamide side effects

38.1% of ethionamide adverse event reports involve female patients and 46.8% involve male patients. The largest age group is adult at 79%. These figures reflect who reports side effects, not underlying risk.

Sex

Female38.1%
Male46.8%
Unknown15.1%

Age group

< 22.5%
2–118.4%
12–174.8%
18–6479.3%
65+5.0%

What is ethionamide used for

Conditions and purposes for which patients were taking ethionamide when the adverse event was reported.

Antibiotic ProphylaxisArachnoiditisBovine TuberculosisBone TuberculosisCardiac DisorderCutaneous TuberculosisDisseminated TuberculosisDrug ResistanceDrug Use For Unknown IndicationDisseminated Bacillus Calmette-guerin InfectionDisseminated TuberculosisExtrapulmonary TuberculosisExtrapulmonary TuberculosisHydrocephalusHypertension

Showing 15 of 42 indications

Ethionamide brand names and reporting trend

Ethionamide is sold under the brand name Trecator.

Brand names

Trecator1,185

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ethionamide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.