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Ethacrynic Side Effects

The most commonly reported side effects of ethacrynic include drug reaction with eosinophilia and systemic symptoms, off label use, and dyspnoea, based on 605 FDA adverse event reports from 2004 to 2025. 5.8% of reports found the drug to be ineffective.

#1 Reported: Drug Reaction With Eosinophilia And Systemic SymptomsAll side effects ↓Top Co-Medication: FurosemideDrug interactions ↓61% of Reports Are ElderlyDemographics ↓

Ethacrynic side effects

Percentages show how often each reaction appears relative to total reports for ethacrynic.

1
Drug Reaction With Eosinophilia And Systemic Symptoms9.8%59
2
Off Label Use8.8%53
3
Dyspnoea7.4%45
4
Nausea6.6%40
5
Acute Kidney Injury6.1%37
6
Drug Ineffective5.8%35
7
Diarrhoea5.6%34
8
Vomiting5.1%31
9
Fatigue5.0%30
10
Drug Hypersensitivity4.8%29
11
Headache4.5%27
12
Dizziness4.1%25
13
Malaise4.1%25
14
Weight Decreased4.0%24
15
Cough3.8%23

These are voluntary reports and do not establish that ethacrynic caused these reactions.

Report severity

71.2%Serious431 reports
39.0%Hospitalizations236 reports
11.2%Fatal68 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ethacrynic drug interactions

Other drugs that appear in adverse event reports alongside ethacrynic. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Furosemide13.6%82
2
Ethacrynate-sodium9.8%59
3
Omeprazole9.6%58
4
Hydroxychloroquine-sulfate9.3%56
5
Midazolam9.3%56
6
Linezolid9.1%55
7
Fentanyl8.8%53
8
Propofol8.8%53
9
Anakinra8.8%53
10
Ritonavir8.6%52
11
Cisatracurium-besylate8.4%51
12
Ceftriaxone-sodium8.3%50
13
Prednisone8.3%50
14
Lopinavir8.3%50
15
Epinephrine7.9%48

Taken alongside

1
Ethacrynate-sodium37.2%225
2
Levothyroxine-sodium18.8%114
3
Ergocalciferol17.9%108
4
Aspirin17.7%107
5
Acetaminophen14.2%86
6
Metoprolol14.0%85
7
Prednisone13.4%81
8
Furosemide13.2%80
9
Omeprazole12.6%76
10
Spironolactone11.4%69
11
Potassium-chloride11.4%69
12
Insulin11.2%68
13
Albuterol9.8%59
14
Lisinopril9.8%59
15
Warfarin9.6%58

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ethacrynic side effects

59.0% of ethacrynic adverse event reports involve female patients and 34.2% involve male patients. The largest age group is elderly at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female59.0%
Male34.2%
Unknown6.8%

Age group

< 22.8%
2–110.9%
12–170.4%
18–6434.6%
65+61.3%

What is ethacrynic used for

Conditions and purposes for which patients were taking ethacrynic when the adverse event was reported.

Blood Pressure AbnormalBlood Pressure AbnormalBlood Pressure MeasurementCardiac DisorderCardiac Failure CongestiveCoronary Artery DiseaseCovid-19Covid-19 PneumoniaCovid-19 PneumoniaCardiac Failure CongestiveClostridium Difficile ColitisDiuretic TherapyDrug HypersensitivityDrug Use For Unknown IndicationDiuretic Therapy

Showing 15 of 55 indications

Ethacrynic brand names and reporting trend

Ethacrynic is sold under the brand name Ethacrynic Acid.

Brand names

Ethacrynic Acid350

Quarterly reports (2004–2025)

20042010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ethacrynic with another medication?

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