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Ethacrynate Side Effects

The most commonly reported side effects of ethacrynate include diarrhoea, vomiting, and nausea, based on 294 FDA adverse event reports from 2004 to 2025. 6.1% of reports found the drug to be ineffective.

Ethacrynate side effects

Percentages show how often each reaction appears relative to total reports for ethacrynate.

1
Diarrhoea7.5%22
2
Vomiting6.8%20
3
Nausea6.5%19
4
Dyspnoea6.1%18
5
Drug Ineffective6.1%18
6
Acute Kidney Injury6.1%18
7
Chronic Kidney Disease5.4%16
8
Cough5.1%15
9
Headache4.4%13
10
Fatigue4.4%13
11
Asthenia4.4%13
12
Malaise4.1%12
13
Off Label Use3.7%11
14
Death3.7%11
15
Rash3.7%11

These are voluntary reports and do not establish that ethacrynate caused these reactions.

Report severity

64.3%Serious189 reports
28.6%Hospitalizations84 reports
9.2%Fatal27 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ethacrynate drug interactions

Other drugs that appear in adverse event reports alongside ethacrynate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ethacrynic-acid20.4%60
2
Ambrisentan4.4%13
3
Esomeprazole4.1%12
4
Omeprazole4.1%12
5
Furosemide3.7%11
6
Pantoprazole-sodium3.4%10
7
Lenalidomide3.4%10
8
Pregabalin2.4%7
9
Adalimumab2.4%7
10
Rivaroxaban2.4%7
11
Amlodipine2.0%6
12
Spironolactone1.7%5
13
Valsartan1.7%5
14
Rosuvastatin1.7%5
15
Apixaban1.7%5

Taken alongside

1
Ethacrynic-acid76.5%225
2
Ergocalciferol23.1%68
3
Aspirin22.4%66
4
Levothyroxine-sodium20.7%61
5
Metoprolol17.3%51
6
Acetaminophen16.3%48
7
Potassium-chloride16.0%47
8
Prednisone15.0%44
9
Omeprazole14.3%42
10
Insulin14.3%42
11
Warfarin12.9%38
12
Amlodipine12.9%38
13
Lisinopril12.6%37
14
Atorvastatin-calcium11.6%34
15
Spironolactone10.5%31

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ethacrynate side effects

71.1% of ethacrynate adverse event reports involve female patients and 24.5% involve male patients. The largest age group is elderly at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female71.1%
Male24.5%
Unknown4.4%

Age group

< 21.4%
2–110.5%
12–170.0%
18–6436.6%
65+61.6%

What is ethacrynate used for

Conditions and purposes for which patients were taking ethacrynate when the adverse event was reported.

Blood Pressure AbnormalCardiac DisorderCardiac Failure CongestiveCardiac Failure CongestiveDiuretic TherapyDrug HypersensitivityDrug Use For Unknown IndicationDiuretic TherapyEdemaEssential HypertensionFluid ImbalanceFluid RetentionFluid RetentionHypersensitivityHypertension

Showing 15 of 35 indications

Ethacrynate brand names and reporting trend

Ethacrynate is sold under the brand name Edecrin.

Brand names

Edecrin10

Quarterly reports (20042025)

20042010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ethacrynate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.