OpenClaim

Estrone Side Effects

The most commonly reported side effects of estrone include breast cancer, breast cancer female, and fatigue, based on 740 FDA adverse event reports from 2004 to 2025. 3.8% of reports found the drug to be ineffective.

Estrone side effects

Percentages show how often each reaction appears relative to total reports for estrone.

1
Breast Cancer7.2%53
2
Breast Cancer Female6.4%47
3
Fatigue4.6%34
4
Nausea4.2%31
5
Pain3.8%28
6
Drug Ineffective3.8%28
7
Dizziness3.5%26
8
Headache3.4%25
9
Oedema Peripheral3.4%25
10
Pain In Extremity2.6%19
11
Insomnia2.6%19
12
Dyspnoea2.6%19
13
Rash2.4%18
14
Depression2.4%18
15
Pruritus2.4%18

These are voluntary reports and do not establish that estrone caused these reactions.

Report severity

62.4%Serious462 reports
23.1%Hospitalizations171 reports
3.6%Fatal27 reports

Seriousness is determined by the reporter, not by OpenClaim.

Estrone drug interactions

Other drugs that appear in adverse event reports alongside estrone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Estrogens14.1%104
2
Medroxyprogesterone-acetate13.8%102
3
Adalimumab10.1%75
4
Estradiol8.0%59
5
Progesterone4.6%34
6
Sodium-oxybate3.8%28
7
Infliximab2.4%18
8
Cyclophosphamide2.4%18
9
Rituximab2.2%16
10
Norethindrone2.0%15
11
Prednisone2.0%15
12
Doxorubicin-hydrochloride2.0%15
13
Vincristine-sulfate1.9%14
14
Niacin1.9%14
15
Estropipate1.8%13

Taken alongside

1
Acetaminophen14.3%106
2
Levothyroxine-sodium14.2%105
3
Ergocalciferol10.5%78
4
Progesterone9.9%73
5
Aspirin9.9%73
6
Omeprazole7.2%53
7
Calcium6.9%51
8
Prednisone6.5%48
9
Albuterol6.2%46
10
Metformin5.9%44
11
Clonazepam5.5%41
12
Cyanocobalamin5.5%41
13
Hydrochlorothiazide5.4%40
14
Gabapentin5.3%39
15
Furosemide4.6%34

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports estrone side effects

93.0% of estrone adverse event reports involve female patients and 4.5% involve male patients. The largest age group is adult at 70%. These figures reflect who reports side effects, not underlying risk.

Sex

Female93.0%
Male4.5%
Unknown2.6%

Age group

< 20.0%
2–111.0%
12–171.0%
18–6469.9%
65+28.0%

What is estrone used for

Conditions and purposes for which patients were taking estrone when the adverse event was reported.

AcneAssisted FertilisationAdverse EventBenign Prostatic HyperplasiaBladder DisorderBlood Oestrogen AbnormalContraceptionCystitisDrug Use For Unknown IndicationDysuriaDysuriaEndometriosisEnd Stage Renal DiseaseEndometrial ThickeningHormone Level Abnormal

Showing 15 of 51 indications

Estrone brand names and reporting trend

Estrone is sold under the brand name Estrogenic Substance.

Brand names

Estrogenic Substance167

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking estrone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.