The most commonly reported side effects of estrogens include breast cancer, breast cancer female, and off label use, based on 70,977 FDA adverse event reports from 2004 to 2025. 4.3% of reports found the drug to be ineffective.
Percentages show how often each reaction appears relative to total reports for estrogens.
These are voluntary reports and do not establish that estrogens caused these reactions.
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Other drugs that appear in adverse event reports alongside estrogens. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
95.6% of estrogens adverse event reports involve female patients and 0.3% involve male patients. The largest age group is adult at 61%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking estrogens when the adverse event was reported.
Showing 15 of 912 indications
Estrogens is sold under brand names including Synthetic Conjugated Estrogens A, Menest.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
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