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Estramustine Side Effects

The most commonly reported side effects of estramustine include prostate cancer, osteonecrosis, and off label use, based on 666 FDA adverse event reports from 2004 to 2025.

Estramustine side effects

Percentages show how often each reaction appears relative to total reports for estramustine.

1
Prostate Cancer7.4%49
2
Osteonecrosis4.5%30
3
Off Label Use4.5%30
4
Anaemia4.4%29
5
Nausea4.4%29
6
Osteonecrosis Of Jaw3.9%26
7
Death3.6%24
8
Prostatic Specific Antigen Increased3.5%23
9
Prostate Cancer Stage Iv3.2%21
10
Interstitial Lung Disease3.2%21
11
Neutropenia3.0%20
12
Nausea2.9%19
13
Metastases To Bone2.7%18
14
Diarrhoea2.6%17
15
Oedema Peripheral2.6%17

These are voluntary reports and do not establish that estramustine caused these reactions.

Report severity

91.9%Serious612 reports
33.0%Hospitalizations220 reports
38.9%Fatal259 reports

Seriousness is determined by the reporter, not by OpenClaim.

Estramustine drug interactions

Other drugs that appear in adverse event reports alongside estramustine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Docetaxel28.4%189
2
Leuprolide13.5%90
3
Zoledronic-acid10.1%67
4
Etoposide7.7%51
5
Paclitaxel7.5%50
6
Doxorubicin-hydrochloride7.1%47
7
Bicalutamide6.9%46
8
Dexamethasone5.6%37
9
Enzalutamide5.4%36
10
Prednisolone5.1%34
11
Carboplatin4.7%31
12
Ketoconazole4.5%30
13
Prednisone3.2%21
14
Bevacizumab2.9%19
15
Cabazitaxel2.9%19

Taken alongside

1
Dexamethasone21.5%143
2
Bicalutamide16.8%112
3
Docetaxel11.9%79
4
Flutamide8.6%57
5
Warfarin7.7%51
6
Zoledronic-acid6.9%46
7
Aspirin6.3%42
8
Leuprolide5.9%39
9
Tamsulosin-hydrochloride5.7%38
10
Oxycodone5.3%35
11
Prednisone5.1%34
12
Furosemide4.2%28
13
Acetaminophen3.6%24
14
Amlodipine3.5%23
15
Goserelin3.3%22

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports estramustine side effects

3.0% of estramustine adverse event reports involve female patients and 87.7% involve male patients. The largest age group is elderly at 81%. These figures reflect who reports side effects, not underlying risk.

Sex

Female3.0%
Male87.7%
Unknown9.3%

Age group

< 20.0%
2–110.4%
12–170.0%
18–6418.6%
65+80.9%

What is estramustine used for

Conditions and purposes for which patients were taking estramustine when the adverse event was reported.

Breast CancerChemotherapyDrug Use For Unknown IndicationGastric CancerHodgkin's Disease Mixed Cellularity Stage IiiHodgkin^s DiseaseHormone-refractory Prostate CancerHormone-refractory Prostate CancerMetastases To BoneMetastases To ProstateMetastases To SpineMetastatic NeoplasmMetastases To BoneNeoadjuvant TherapyNeoplasm Malignant

Showing 15 of 36 indications

Estramustine brand names and reporting trend

Estramustine is sold under the brand name Emcyt.

Brand names

Emcyt554

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking estramustine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.