The most commonly reported side effects of estradiol include off label use, product adhesion issue, and headache, based on 101,534 FDA adverse event reports from 2004 to 2025. 7.8% of reports found the drug to be ineffective.
Percentages show how often each reaction appears relative to total reports for estradiol.
These are voluntary reports and do not establish that estradiol caused these reactions.
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Other drugs that appear in adverse event reports alongside estradiol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
90.2% of estradiol adverse event reports involve female patients and 1.8% involve male patients. The largest age group is adult at 69%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking estradiol when the adverse event was reported.
Showing 15 of 1,378 indications
Estradiol is sold under several brand names including Estradiol And Norgestimate, Ditate-ds, Estrasorb.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
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