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Estazolam Side Effects

The most commonly reported side effects of estazolam include drug interaction, pneumonia, and pyrexia, based on 2,085 FDA adverse event reports from 2004 to 2025. 3.5% of reports found the drug to be ineffective.

Estazolam side effects

Percentages show how often each reaction appears relative to total reports for estazolam.

1
Drug Interaction5.9%123
2
Pneumonia3.7%78
3
Drug Ineffective3.5%74
4
Pyrexia3.5%73
5
Toxicity To Various Agents3.3%69
6
Somnolence3.1%64
7
Vomiting3.0%62
8
Asthenia2.9%61
9
Insomnia2.9%61
10
Nausea2.8%59
11
Suicide Attempt2.8%58
12
Off Label Use2.6%54
13
Overdose2.6%54
14
Diarrhoea2.6%54
15
Dizziness2.6%54

These are voluntary reports and do not establish that estazolam caused these reactions.

Report severity

87.3%Serious1,821 reports
52.8%Hospitalizations1,100 reports
15.5%Fatal323 reports

Seriousness is determined by the reporter, not by OpenClaim.

Estazolam drug interactions

Other drugs that appear in adverse event reports alongside estazolam. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Quetiapine-fumarate5.4%112
2
Alprazolam4.6%95
3
Lorazepam3.7%78
4
Aripiprazole3.4%71
5
Risperidone3.4%70
6
Adalimumab3.4%70
7
Zolpidem-tartrate3.1%64
8
Diazepam3.0%62
9
Paroxetine2.9%61
10
Atezolizumab2.8%59
11
Carboplatin2.7%57
12
Olanzapine2.7%56
13
Venlafaxine2.3%47
14
Mirtazapine2.2%45
15
Tramadol-hydrochloride2.1%43

Taken alongside

1
Acetaminophen10.8%226
2
Furosemide10.0%208
3
Omeprazole9.2%191
4
Aspirin9.2%191
5
Amlodipine7.6%159
6
Potassium-chloride7.1%149
7
Alprazolam7.1%148
8
Atorvastatin-calcium6.7%139
9
Dexamethasone6.6%138
10
Levothyroxine-sodium6.1%128
11
Zolpidem-tartrate5.8%120
12
Pantoprazole-sodium5.6%117
13
Metoprolol5.4%113
14
Lorazepam5.3%110
15
Lansoprazole5.1%106

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports estazolam side effects

55.4% of estazolam adverse event reports involve female patients and 37.7% involve male patients. The largest age group is adult at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female55.4%
Male37.7%
Unknown6.9%

Age group

< 20.2%
2–110.1%
12–171.2%
18–6460.1%
65+38.4%

What is estazolam used for

Conditions and purposes for which patients were taking estazolam when the adverse event was reported.

Acute Myeloid LeukaemiaAlcoholic PsychosisAlcoholismAnxietyAnxiety DisorderAggressionAnaemiaAnalgesic TherapyAntipsychotic TherapyAnxietyAnxiety DisorderAnxiolytic TherapyBack PainBipolar DisorderBipolar Ii Disorder

Showing 15 of 118 indications

Estazolam brand names and reporting trend

Estazolam is sold under the brand name Prosom.

Brand names

Prosom2,227

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking estazolam with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.