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Escitalopram Side Effects

The most commonly reported side effects of escitalopram include fatigue, nausea, and headache, based on 139,123 FDA adverse event reports from 2004 to 2025. 5.5% of reports found the drug to be ineffective.

Escitalopram side effects

Percentages show how often each reaction appears relative to total reports for escitalopram.

1
Fatigue5.7%7,903
2
Drug Ineffective5.5%7,620
3
Nausea5.3%7,314
4
Headache4.3%5,993
5
Off Label Use4.2%5,870
6
Diarrhoea4.1%5,733
7
Anxiety3.7%5,090
8
Dizziness3.5%4,889
9
Pain3.3%4,566
10
Fall3.2%4,484
11
Depression3.2%4,474
12
Dyspnoea3.1%4,294
13
Vomiting2.9%4,016
14
Asthenia2.5%3,516
15
Insomnia2.5%3,435

These are voluntary reports and do not establish that escitalopram caused these reactions.

Report severity

67.8%Serious94,350 reports
31.9%Hospitalizations44,368 reports
8.1%Fatal11,264 reports

Seriousness is determined by the reporter, not by OpenClaim.

Escitalopram drug interactions

Other drugs that appear in adverse event reports alongside escitalopram. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab3.4%4,782
2
Quetiapine-fumarate3.4%4,695
3
Sodium-oxybate2.9%4,073
4
Lenalidomide2.3%3,269
5
Acetaminophen2.1%2,962
6
Aripiprazole2.1%2,950
7
Dupilumab2.0%2,787
8
Bupropion1.9%2,667
9
Omeprazole1.9%2,594
10
Venlafaxine1.7%2,341
11
Olanzapine1.7%2,305
12
Sertraline-hydrochloride1.6%2,279
13
Lamotrigine1.5%2,133
14
Pregabalin1.5%2,115
15
Alprazolam1.5%2,022

Taken alongside

1
Acetaminophen13.0%18,028
2
Ergocalciferol11.6%16,186
3
Levothyroxine-sodium11.6%16,127
4
Aspirin10.7%14,914
5
Omeprazole9.2%12,810
6
Atorvastatin-calcium9.2%12,763
7
Gabapentin8.9%12,397
8
Albuterol7.9%10,929
9
Pantoprazole-sodium7.4%10,359
10
Alprazolam7.0%9,777
11
Metoprolol6.7%9,325
12
Furosemide6.6%9,234
13
Amlodipine6.6%9,212
14
Fluticasone6.6%9,125
15
Metformin6.1%8,481

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports escitalopram side effects

63.6% of escitalopram adverse event reports involve female patients and 28.7% involve male patients. The largest age group is adult at 65%. These figures reflect who reports side effects, not underlying risk.

Sex

Female63.6%
Male28.7%
Unknown7.6%

Age group

< 21.1%
2–110.4%
12–172.6%
18–6464.5%
65+31.4%

What is escitalopram used for

Conditions and purposes for which patients were taking escitalopram when the adverse event was reported.

Abdominal AdhesionsAbdominal DiscomfortAbdominal DistensionAbdominal PainAbnormal BehaviourAbortion SpontaneousAbscessAccident At WorkAccidental Exposure To ProductAccidental Exposure To Product By ChildAcidosisAcneAcute PsychosisAcute Stress DisorderAdjustment Disorder

Showing 15 of 984 indications

Escitalopram brand names and reporting trend

Escitalopram is sold under the brand name Lexapro.

Brand names

Lexapro19,277

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking escitalopram with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.