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Ertugliflozin Side Effects

The most commonly reported side effects of ertugliflozin include nausea, product dose omission issue, and vomiting, based on 1,249 FDA adverse event reports from 2013 to 2025. 3.9% of reports found the drug to be ineffective.

Ertugliflozin side effects

Percentages show how often each reaction appears relative to total reports for ertugliflozin.

1
Nausea7.4%92
2
Product Dose Omission Issue7.0%87
3
Vomiting6.3%79
4
Urinary Tract Infection5.5%69
5
No Adverse Event5.5%69
6
Fungal Infection5.0%63
7
Diabetic Ketoacidosis4.8%60
8
Blood Glucose Increased4.7%59
9
Diarrhoea3.9%49
10
Drug Ineffective3.9%49
11
Dizziness3.8%48
12
Product Dose Omission2.8%35
13
Rash2.6%32
14
Dyspnoea2.4%30
15
Product Use Issue2.3%29

These are voluntary reports and do not establish that ertugliflozin caused these reactions.

Report severity

45.5%Serious568 reports
28.8%Hospitalizations360 reports
1.4%Fatal18 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ertugliflozin drug interactions

Other drugs that appear in adverse event reports alongside ertugliflozin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Metformin12.6%157
2
Sitagliptin10.6%132
3
Semaglutide3.3%41
4
Carvedilol2.6%33
5
Dulaglutide2.6%32
6
Insulin2.5%31
7
Torsemide2.3%29
8
Spironolactone2.1%26
9
Aspirin1.8%22
10
Atorvastatin-calcium1.5%19
11
Amiodarone-hydrochloride1.5%19
12
Ramipril1.5%19
13
Empagliflozin1.4%17
14
Tamsulosin-hydrochloride1.4%17
15
Prednisolone1.1%14

Taken alongside

1
Metformin23.3%291
2
Insulin11.3%141
3
Atorvastatin-calcium11.0%138
4
Lisinopril7.2%90
5
Sitagliptin7.2%90
6
Aspirin6.8%85
7
Levothyroxine-sodium5.0%63
8
Metoprolol4.8%60
9
Albuterol4.6%58
10
Omeprazole4.4%55
11
Gabapentin4.2%53
12
Ergocalciferol4.2%52
13
Furosemide3.8%48
14
Apixaban3.8%47
15
Amlodipine3.5%44

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ertugliflozin side effects

49.3% of ertugliflozin adverse event reports involve female patients and 45.2% involve male patients. The largest age group is adult at 68%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.3%
Male45.2%
Unknown5.4%

Age group

< 20.0%
2–110.3%
12–170.0%
18–6468.5%
65+31.2%

What is ertugliflozin used for

Conditions and purposes for which patients were taking ertugliflozin when the adverse event was reported.

ArrhythmiaBlood GlucoseBlood Glucose AbnormalBlood Glucose IncreasedBlood Pressure ManagementBlood GlucoseBlood Glucose AbnormalBlood Glucose IncreasedCardiac FailureCardiac Function Test AbnormalColon CancerDiabetes MellitusDiabetes Mellitus Inadequate ControlDiabetes Mellitus ManagementDiabetes Mellitus

Showing 15 of 43 indications

Ertugliflozin brand names and reporting trend

Ertugliflozin is sold under the brand name Segluromet.

Brand names

Segluromet178

Quarterly reports (20132025)

2013202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ertugliflozin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.