OpenClaim

Eravacycline Side Effects

The most commonly reported side effects of eravacycline include off label use, blood fibrinogen decreased, and nausea, based on 207 FDA adverse event reports from 2011 to 2025. 11.6% of reports found the drug to be ineffective.

Eravacycline side effects

Percentages show how often each reaction appears relative to total reports for eravacycline.

1
Off Label Use30.0%62
2
Drug Ineffective11.6%24
3
Blood Fibrinogen Decreased7.7%16
4
Nausea7.2%15
5
Thrombocytopenia6.8%14
6
Product Use In Unapproved Indication6.3%13
7
Multiple Organ Dysfunction Syndrome6.3%13
8
Lactic Acidosis5.3%11
9
Diarrhoea4.8%10
10
Hypertransaminasaemia4.8%10
11
Pancreatitis3.9%8
12
Drug Intolerance2.9%6
13
Sepsis2.9%6
14
Enterococcal Infection2.9%6
15
Condition Aggravated2.9%6

These are voluntary reports and do not establish that eravacycline caused these reactions.

Report severity

67.1%Serious139 reports
27.5%Hospitalizations57 reports
15.9%Fatal33 reports

Seriousness is determined by the reporter, not by OpenClaim.

Eravacycline drug interactions

Other drugs that appear in adverse event reports alongside eravacycline. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Linezolid10.6%22
2
Imipenem9.2%19
3
Azithromycin8.7%18
4
Meropenem7.2%15
5
Cefiderocol-sulfate-tosylate6.8%14
6
Amikacin-sulfate6.3%13
7
Tigecycline5.8%12
8
Vancomycin5.8%12
9
Daptomycin5.3%11
10
Cilastatin-sodium4.3%9
11
Cefepime-hydrochloride4.3%9
12
Methylprednisolone4.3%9
13
Tedizolid-phosphate3.9%8
14
Metronidazole3.9%8
15
Mycophenolate3.4%7

Taken alongside

1
Azithromycin10.6%22
2
Meropenem10.6%22
3
Amikacin-sulfate8.7%18
4
Linezolid7.2%15
5
Vancomycin6.8%14
6
Tedizolid-phosphate5.8%12
7
Imipenem4.8%10
8
Tigecycline4.8%10
9
Micafungin-sodium4.3%9
10
Ganciclovir3.9%8
11
Cefepime-hydrochloride3.9%8
12
Cefiderocol-sulfate-tosylate3.9%8
13
Clofazimine3.9%8
14
Omadacycline-tosylate3.9%8
15
Polymyxin-b-sulfate3.4%7

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports eravacycline side effects

25.6% of eravacycline adverse event reports involve female patients and 45.9% involve male patients. The largest age group is adult at 68%. These figures reflect who reports side effects, not underlying risk.

Sex

Female25.6%
Male45.9%
Unknown28.5%

Age group

< 20.0%
2–110.7%
12–170.7%
18–6468.3%
65+30.3%

What is eravacycline used for

Conditions and purposes for which patients were taking eravacycline when the adverse event was reported.

Abdominal InfectionAbscessAcinetobacter InfectionAntibiotic TherapyAbdominal InfectionAcinetobacter InfectionAcinetobacter Test PositiveAnti-infective TherapyAntibiotic ProphylaxisAntibiotic TherapyAntifungal ProphylaxisBacteraemiaBacterial InfectionBacteraemiaBacterial Infection

Showing 15 of 74 indications

Eravacycline brand names and reporting trend

Eravacycline is sold under the brand name Xerava.

Brand names

Xerava135

Quarterly reports (20112025)

2011202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking eravacycline with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.