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Eptinezumab Side Effects

The most commonly reported side effects of eptinezumab include migraine, headache, and therapeutic response shortened, based on 8,173 FDA adverse event reports from 2020 to 2025. 24.0% of reports found the drug to be ineffective.

Eptinezumab side effects

Percentages show how often each reaction appears relative to total reports for eptinezumab.

1
Drug Ineffective24.0%1,960
2
Migraine16.8%1,373
3
Headache11.1%908
4
Therapeutic Response Shortened6.3%513
5
Nausea6.2%504
6
Fatigue5.6%455
7
Drug Effect Less Than Expected4.1%337
8
Throat Irritation3.9%322
9
Dizziness3.8%309
10
Pruritus3.5%284
11
Nasal Congestion2.8%228
12
Hypersensitivity2.2%182
13
Dyspnoea2.2%182
14
Vomiting2.2%182
15
Malaise2.0%162

These are voluntary reports and do not establish that eptinezumab caused these reactions.

Report severity

22.2%Serious1,812 reports
6.8%Hospitalizations553 reports
0.6%Fatal50 reports

Seriousness is determined by the reporter, not by OpenClaim.

Eptinezumab drug interactions

Other drugs that appear in adverse event reports alongside eptinezumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Onabotulinumtoxina0.6%47
2
Galcanezumab-gnlm0.3%28
3
Sumatriptan0.3%24
4
Sodium-oxybate0.3%21
5
Amitriptyline-hydrochloride0.2%19
6
Rimegepant0.2%17
7
Pregabalin0.2%17
8
Dupilumab0.2%15
9
Fremanezumab-vfrm0.2%15
10
Erenumab-aooe0.2%14
11
Atogepant0.2%14
12
Oxycodone0.2%13
13
Oxcarbazepine0.1%12
14
Prednisolone0.1%12
15
Topiramate0.1%10

Taken alongside

1
Onabotulinumtoxina4.8%395
2
Acetaminophen4.0%323
3
Ubrogepant3.9%322
4
Ondansetron3.7%301
5
Rimegepant3.7%301
6
Topiramate3.5%287
7
Gabapentin3.2%264
8
Sumatriptan3.2%262
9
Ergocalciferol3.1%253
10
Levothyroxine-sodium2.8%230
11
Duloxetine-hydrochloride2.6%209
12
Albuterol2.5%203
13
Rizatriptan-benzoate2.3%185
14
Diphenhydramine2.0%166
15
Omeprazole2.0%166

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports eptinezumab side effects

59.4% of eptinezumab adverse event reports involve female patients and 9.7% involve male patients. The largest age group is adult at 85%. These figures reflect who reports side effects, not underlying risk.

Sex

Female59.4%
Male9.7%
Unknown30.9%

Age group

< 20.1%
2–11<0.1%
12–170.3%
18–6485.1%
65+14.5%

What is eptinezumab used for

Conditions and purposes for which patients were taking eptinezumab when the adverse event was reported.

Abdominal MigraineAsthmaAutonomic NeuropathyCervicogenic HeadacheCluster HeadacheConcussionCongenital NeuropathyDepressionDizzinessEncephalitisFoetal Exposure During PregnancyGastrooesophageal Reflux DiseaseHeadacheHemiplegic MigraineHeadache

Showing 15 of 47 indications

Eptinezumab brand names and reporting trend

Eptinezumab is sold under the brand name Vyepti.

Brand names

Vyepti76

Quarterly reports (20202025)

2020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking eptinezumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.