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Eptifibatide Side Effects

The most commonly reported side effects of eptifibatide include myocardial infarction, thrombocytopenia, and hypotension, based on 2,451 FDA adverse event reports from 2004 to 2025. 3.0% of reports found the drug to be ineffective.

Eptifibatide side effects

Percentages show how often each reaction appears relative to total reports for eptifibatide.

1
Myocardial Infarction10.9%266
2
Thrombocytopenia8.5%208
3
Hypotension4.3%105
4
Thrombocytopenia3.9%96
5
Renal Failure3.4%84
6
Haemorrhage3.3%80
7
Platelet Count Decreased3.1%77
8
Drug Ineffective3.0%74
9
Post Procedural Complication3.0%73
10
Haemorrhage Intracranial2.9%71
11
Pain2.9%70
12
Anxiety2.7%66
13
Injury2.7%66
14
Product Use In Unapproved Indication2.6%63
15
Death2.5%62

These are voluntary reports and do not establish that eptifibatide caused these reactions.

Report severity

81.9%Serious2,008 reports
40.5%Hospitalizations993 reports
21.7%Fatal531 reports

Seriousness is determined by the reporter, not by OpenClaim.

Eptifibatide drug interactions

Other drugs that appear in adverse event reports alongside eptifibatide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Heparin26.7%654
2
Aspirin12.0%293
3
Abciximab8.4%207
4
Clopidogrel-bisulfate7.8%192
5
Gemfibrozil6.2%152
6
Bivalirudin5.9%144
7
Enoxaparin-sodium5.9%144
8
Prasugrel-hydrochloride4.5%111
9
Ticagrelor4.2%102
10
Aprotinin2.5%61
11
Alteplase1.3%31
12
Tenecteplase1.2%29
13
Cangrelor1.1%28
14
Metoprolol0.9%23
15
Nitroglycerin0.9%22

Taken alongside

1
Aspirin30.1%737
2
Heparin21.3%523
3
Clopidogrel-bisulfate15.4%378
4
Nitroglycerin13.3%326
5
Metoprolol11.4%280
6
Gemfibrozil8.0%196
7
Midazolam7.5%184
8
Fentanyl7.5%183
9
Atorvastatin-calcium7.3%178
10
Furosemide6.2%153
11
Simvastatin5.7%140
12
Famotidine5.0%122
13
Enoxaparin-sodium4.9%121
14
Lisinopril4.9%121
15
Acetaminophen4.4%108

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports eptifibatide side effects

25.2% of eptifibatide adverse event reports involve female patients and 52.2% involve male patients. The largest age group is adult at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female25.2%
Male52.2%
Unknown22.6%

Age group

< 20.3%
2–110.3%
12–170.4%
18–6452.5%
65+46.6%

What is eptifibatide used for

Conditions and purposes for which patients were taking eptifibatide when the adverse event was reported.

Acute Coronary SyndromeAcute Myocardial InfarctionAdjuvant TherapyAge Indeterminate Myocardial InfarctionAmyotrophic Lateral SclerosisAneurysm RepairAngina PectorisAngina UnstableAngiogramAngioplastyAnterior Spinal Artery SyndromeAnticoagulant TherapyAntiplatelet TherapyArterial CatheterisationArterial Occlusive Disease

Showing 15 of 149 indications

Eptifibatide brand names and reporting trend

Eptifibatide is sold under the brand name Eptifibatide.

Brand names

Eptifibatide1,012

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking eptifibatide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.